EFFECTS OF L-CARNITINE ON VENTRICULAR ARRHYTHMIAS AFTER CORONARY REPERFUSION
スポンサーリンク
概要
- 論文の詳細を見る
Effects of L-carnitine on ventricular arrhythmias and myocardial metabolism in a reperfused ischemic myocardium were studied in 35 anesthetized mongrel dogs. The left anterior descending coronary artery was ligated for 40 min and then reperfused for 15 min. L-carnitine (100 mg/kg) was administered intravenously 5 min before the coronary ligation and infused continuously at a rate of 20 mg/kg/min from 5 min before the reperfusion to the end of the experiment. Electrocardiograms were recorded continuously throughout the experiment. Transmural myocardial samples were obtained from both the ischemic and the nonischemic areas after 15 min of reperfusion and used for the determination of ATP, free carnitine, long chain acyl carnitine and long chain acyl CoA. L-carnitine significantly reduced the incidence rate of ventricular fibrillation after reperfusion (from 29% in the controls to 5%, p < 0.05). ATP in the ischemic myocardium in the L-carnitine group was significantly higher than that in the control group (p < 0.05). Free carnitine in the control group significantly decreased in the ischemic area as compared with the nonischemic area (p < 0.01). In L-carnitine group, on the other hand, no difference was observed between them. Long chain acyl CoA in the control group significantly increased in the ischemic area as compared with the nonischemic area (p < 0.01). In L-carnitine group, on the other hand, no difference was observed between them. Thus, the accumulation of long chain acyl CoA in the ischemic myocardium was reduced by the L-carnitine treatment. These data suggest that L-carnitine has protective effects on ventricular arrhythmias and on metabolic changes after coronary artery reperfusion following coronary artery occlusion.
- 社団法人日本循環器学会の論文
- 1983-05-20
著者
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Yamazaki Noboru
The Third Department of Internal Medicine
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KOBAYASHI AKIRA
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Nishihara Kenji
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Suzuki Yoshikazu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Kamikawa Tadashi
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Hayashi Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Masumura Yoshinori
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Yamazaki Noboru
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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ABE MASAAKI
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Kobayashi Akira
The Department Of Medicine Iii Hamamatsu University School Of Medicine
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Abe M
The 3rd Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kondo Takasi
2nd Dept. Of Intern. Med. Nagoya Univ. School Of Med.
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Kobayashi Akira
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Suzuki Yoshikazu
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kamikawa Tadashi
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Masumura Yoshinori
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Suzuki Yoshikazu
The 2nd Dept. Of Intern Med. Nagoya Univ. School. Of Med.
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HAYASHI Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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