ARRHYTHMIA AFTER THE RELEASE OF INHIBITED OXIDATIVE PHOSPHORYLATION : The 53th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
Automaticities due to delayed afterdepolarizations. elicited upon reoxygenation, are thought to be caused by Ca overload. Since tissue Ca uptake upon reoxygenation has been reported to be closely related to metabolic inhibition during hypoxic perfusion. the relationship between the degree of metabolic inhibition during hypoxia and reoxygenation-induced arrhythmias was investigated in guinea pig papillary muscles. (1) Arrhythmias occurred after 60 min substrate-free hypoxia. but not after 30 min hypoxia. The chance of automaticities was closely related with the increase in resting tention achieved during hypoxic period. The incidence of arrhythmias was. however. lower after 90 or 120 min hypoxia. (2) There were arrhythmias after 20-30 min hypoxia with glycolytic inhibition (20 mM 2-deoxyglucose + 5 mM acetate). On the other hand. 60-min hypoxia in the presence of _5 mM glucose did not elicit arrhythmias on reoxygenation. (3) Stimulation of glycolysis (50 mM glucose) during substrate-free hypoxia prolonged the action potential duration. but did not cause arrhythmias. Washout of cyanide (1 mM) after 60 min perfusion in the presence of oxygen, caused arrhythmias and aftercontractions. These results suggest that the degree of metabolic inhibition during hypoxia is closely related to Ca overload and the resultant arrhythmias upon reoxygena-tion. The release of inhibited oxidative phosphoryiation, rather than the reintroduction of oxygen per se, was thought to be the key mechanism of reoxygenation-induced arrhythmias.
- 社団法人日本循環器学会の論文
- 1990-06-20
著者
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Terada Hajime
The Third Department of Internal Medicine
-
Yamazaki Noboru
The Third Department of Internal Medicine
-
Hayashi Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Kobayashi Akira
The Department Of Medicine Iii Hamamatsu University School Of Medicine
-
Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kobayashi Akira
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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MCDONALD TERENCE
Department of Physiology and Biophysics, Dalhausie University
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Mcdonald Terence
Department Of Physiology And Biophysics Dalhausie University
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