EFFECTS OF GLUCOSE-INSULIN-POTASSIUM SOLUTION ON FREE FATTY ACID METABOLISM IN ISCHEMIC MYOCARDIUM
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概要
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The accumulation of intermediates subsequent to impaired oxidation of free fatty acids has been suggested as a cause of cellular damage in ischemic myocardium. Many reviews have supported the theory that glucose-insulin-potassium (GIK) solution has a beneficial effect on the ischemic myocardium. We evaluated the effects of GIK solution on intermediates of free fatty acid metabolism in ischemic myocardium. The left coronary artery was occluded for 40 minutes in twelve dogs. In six dogs, 10 minutes before coronary artery occlusion, GIK solution (50 per cent of glucose, 50 units/liter of regular insulin, 50 mEq/ liter of potassium) was given at the rate of 0.1 ml/kg per minute until the time of excision of the hear. In the ischemic area, adenosine triphosphate (ATP) level in the GIK group (3.80±1.34 μmole/g) was significantly higher than that in the control group (2.04±0.68, p<0.05). The free carnitine level was significantly increased was GIK in both ischemic and nonischemic areas (p<0.05). In the control group, the long chain acyl coenzyme A (CoA) level in the ischemic area (23.0±7.0 nmole/g) was significantly higher than that in the nonischemic area (1.71±3.5, p< 0.05). On the other hand, GIK prevented the increase in the long chain acyl CoA in the ischemic area (17.8±5.6). This study suggests that GIK has a protective effect on ischemic myocardium, probably by preventing the accumulation of long chain acyl CoA by improving free fatty acid metabolism.
- 社団法人日本循環器学会の論文
- 1984-06-20
著者
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Yamazaki Noboru
The Third Department of Internal Medicine
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Ishizaka Kyoichi
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Hayashi Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu
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Yamashita Tesuo
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kobayashi Akira
The Department Of Medicine Iii Hamamatsu University School Of Medicine
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Kondo Takasi
2nd Dept. Of Intern. Med. Nagoya Univ. School Of Med.
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Kobayashi Akira
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Yamashita T
Hiroshima Univ. Hiroshima Jpn
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Ishizaka Kyoichi
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kamikawa Tadashi
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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KAMIYA JUN
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Kamiya Jun
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Ishizaka Kyoichi
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Ishizaka Kyoichi
Department Of Cardiology Hamamatsu Medical Cente
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Ishizaka Kyouichi
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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HAYASHI Hideharu
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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