DUAL-TRACER AUTORADIOGRAPHY WITH THALLIUM-201 AND IODINE-125 MIBG IN BIO 14.6 CARDIOMYOPATHIC SYRIAN HAMSTERS
スポンサーリンク
概要
- 論文の詳細を見る
Dual-tracer imaging of the heart with ^<125>I-metaiodobenzylguanicline (MIBG) and ^<201>Tl can simultaneously demonstrate the distribution of sympathetic nerve endings and the underlying myocardial perfusion. A quantitative dual-tracer autoradiographic study with ^<201>Tl and 1251-MIBG was performed to investigate changes in the distribution of cardiac sympathetic innervation with the progression of cardiomyopathy in BIO 14.6 hamsters. The distribution of ^<201>Tl was uniform in control hamsters and BIO 14.6 hamsters at all stages of cardiomyopathy. In contrast, a reduction in MIBG accumulation occurred in the endocardial region of the left ventricular free wall and the left ventricular aspect of the interventricular septurn in BIO 14.6 hamsters at 3 and 8 months of age. Thus, there was an uncoupling of the left ventricular distribution of ^<201>T1 and ^<125>I-MIBG in BIO 14.6 hamsters. In addition, interstitial fibrosis was increased in the interventricular septum, the subendocardial region of the left ventricular free wall, and the right ventricular wall, which were the sites of reduced MIBG accumulation. This study shows that dual myocardial imaging with MIBG and ^<201>Tl may be useful for investigating patients with cardiomyopathy.
- 社団法人日本循環器学会の論文
- 1993-10-20
著者
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Yamazaki Noboru
The Third Department of Internal Medicine
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KOBAYASHI AKIRA
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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KURATA Chinori
YAMAHA Health Care Center
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Tawarahara Kei
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Yamazaki Noboru
Third Division Department Of Internal Medicine Hamamatsu University School Of Medicine
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Yamazaki Noboru
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kobayashi Akira
The Department Of Medicine Iii Hamamatsu University School Of Medicine
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Taguchi Takahisa
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kobayashi Akira
Internal Medicine Iii Hamamatsu University School Of Medicine
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Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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KURATA CHINORI
The Third Department of Internal Medicine, Hamamatsu University School of Medicine
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Kurata Chinori
Department Of Medicine Iii Hamamatsu University School Of Medicine
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Kobayashi Akira
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Yamazaki Noburu
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kurata Chinori
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Yamazaki Noboru
The 2nd Dept. Of Intern Med. Nagoya Univ. School. Of Med.
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Yamazaki Noboru
Nanotechnology Research Institute National Institute Of Advanced Industrial Science And Technology (
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