MYOCARDIAL FREE CARNITINE AND FATTY ACYLCARNITINE LEVELS IN PATIENTS WITH CHRONIC HEART FAILURE
スポンサーリンク
概要
- 論文の詳細を見る
To study the tissue carnitine level in patients with chronic heart failure, we obtained biopsy specimens of the left ventricular papillary muscle from 8 patients with mitral valve disease undergoing valve replacement surgery. As a control group autopsy specimens from 7 patients without heart disease were obtained within 4 hours of death. The free carnitine level in the heart was significantly lower in patients with chronic heart failure than in the control group (412±142 nmol/g wet tissue vs 769±267; p<0.01, mean±SD). The long-chain acylcarnitine level was significantly higher in chronic heart failure than in the control group (532±169 nmol/g wet tissue vs 317±72; p<0.01). The total carnitine level in chronic heart failure was similar to that in the control group (1321±170 nmol/g wet tissue vs 1315±377) . These results show that in failing myocardium the fatty acid metabolism may be impaired, and administration of carnitine may be worth trying to treat chronic heart failure.
- 社団法人日本循環器学会の論文
- 1990-12-20
著者
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Yamazaki Noboru
The Third Department of Internal Medicine
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Kobayashi Akira
The Department Of Medicine Iii Hamamatsu University School Of Medicine
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Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Kobayashi Akira
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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Masumura Yoshinori
The Third Department Of Internal Medicine Hamamatsu University School Of Medicine
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