ROLE OF_<α1> -ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6

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In order to clarify the pathological involvement of the sympathetic nervous system in the development of cardiomyopathy, a receptor-binding study was carried out on cardiomyopathic Syrian hamsters of strain BIO 14.6 (BIO) at 21 days (prenecrotic stage); 35-42 days (onset of cardiomyopathy); and 70-84 days of life (early cardiac hypertrophy). The newly developed α_1-blocker (bunazosin hydrochloride) was initially administered at doses of 100 μg/kg or 10 mg/kg BIO hamsters at 21 days of life and continued for 70 days. At the onset of cardiomyopathy and early cardiac hypertrophy, there was an increase in the number of α_1-receptors in the BIO hamsters compared to controls, but there were no significant changes at the prenecrotic stage. On histopathological examination, 10 mg/kg bunazosin had a singnificant beneficial effect on cardiomyopathy [area of necrosis 1.38% in untreated vs 0.33% in treated animals; area of calcification 2.70% (untreated) vs 0.60% (treated); area of all myocardial injuries 6.97% (untreated) vs 3.19% (treated)]. However, 100 g/kg bunazosin had no effect. It was concluded that the increase in the number of _1-receptors may not be involved in the pathogenesis of cardiomyopathy but that _1-receptors could be implicated in the later progression of the condition.
社団法人日本循環器学会の論文
1988-02-20