Effects of pantethine on action potential of canine papillary muscle during hypoxic perfusion.
スポンサーリンク
概要
- 論文の詳細を見る
Pantethine, which is known to be converted to coenzyme A, has been reported to have antiarrhythmic action on experimental cardiac arrhythmias. Using standard microelectrode techniques, the electrophysiological effects of pantethine under hypoxic (95% N2+5% CO2) perfusion were studied.Hypoxia decreased resting membrane potential, action potential amplitude and maximum velocity of phase 0 and shortened action potential duration and effective refractory period. Application of pantethine 5×10-3Gm/ml under hypoxic perfusion prolonged action potential duration and effective refractory period significantly. Prolongation of action potential duration by pantethine might be caused by an increase in intracellular ATP.The findings in this study could be an explanation of the possible antiarrhythmic effects of pantethine.
- International Heart Journal刊行会の論文
著者
-
Hayashi Hideharu
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Kobayashi Akira
Third Department of Internal Medicine, Hamamatsu University School of Medicine
-
Yamazaki Noboru
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Terada Hajime
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Nagao Bunnosuke
Third Department of Internal Medicine Hamamatsu University School of Medicine
-
Nishiyama Terumasa
Third Department of Internal Medicine Hamamatsu University School of Medicine
-
Kamikawa Tadashi
Third Department Of Internal Medicine Aichi Medical University
関連論文
- P392 Effects of Mg^ on the Ca^ birnding capacity and Ca^ uptake activity of the sarcoplasmic reticulum
- 0168 THE ROLE OF GLYCOLYSIS AND OXIDATIVE PHOSPHORYLATION IN THE REGULATION OF Na^+-H^+ EXCHANGE-STUDY USING ISOLATED VENTRICULAR MYOCYTES
- 0155 ROLES OF INHIBITORS OF TYROSINE KINASE AND MYOSINE LIGHT CHAIN KINASE ON CATION INFLUX IN AGONIST-STIMULATED ENDOTHELIAL CELLS
- P405 ANALYSIS OF THE MODEL OF REPERFUSION INJURY USING SINGLE MYOCARDIAL CELLS : REGULATIONS OF[Na^+]i, AND[Ca^]i, AND CONTRIBUTION OF SARCOPLASMIC RETICULUM(SR)
- P404 THE ROLE OF Na^+/H^+ EXCHANGER IN THE CHANGES OF[Na^+]i DURING ISCHEMIA IN GUINEA PIG MYOCYTES.
- 0087 Modulation of macromolecule permeability across endothelial monolayer membrane by extracellular pH.
- 0086 THE CHANGES OF[Na^+]i AND pHi DURING ACIDIC REPERFUSION IN GUINEA PIG MYOCYTES
- -P188- IMPAIRED PHOSPHOCREATINE SHUTTLE IN DIABETIC CARDIOMYOPATHY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0938- THE CHANGES IN[Na^+]i DURING METABOLIC INHIBITION : THE ROLES OF Na^+/H^+ EXCHANGE AND THE Na^+/K^+ PUMP IN THE REGULATION OF[Na^+]i(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0504- THE RELATIONSHIP BETWEEN [Na^+]i AND Ca^ TRANSIENTS IN DIGITALIS-INDUCED ARRHYTHMIAS : A STUDY USING DUAL-LOADING METHOD OF FLUORESCENT INDICATIORS.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- EFFICACY OF COMBINATION THERAPY WITH MEXILETINE AND A LOW DOSE OF PROPRANOLOL FOR PREMATURE VENTRICULAR ARRHYTHMIAS
- Long-Term Survival in Patients with Pulmonary Hypertension Treated with a Type 5 Phosphodiesterase Inhibitor Sildenafil(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Involvement of [Na^+]_i and Na^+/Ca^ Exchanger in the Negative Inotropic Effect of a Na^+ Channel Blocker in Guinea-pig Ventricular Myocytes(Arrhythmia, Pharmacological Therapy 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Soci
- PJ-458 The Acute Phase Effects of Combined Reperfusion Therapy by tPA and Angioplasty for Acute Myocardial Infarction : Analysis by Hamamatsu-PACT Trial(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PJ76)(Poster Session (Japanese)
- COMPARISON AMONG PLASMA NOREPINEPHRINE LEVELS, HEART RATE VARIABILITY, AND MYOCARDIAL IMAGING WITH ^I-METAIODOBENZYLGUANIDINE (MIBG)
- CARDIAC AUTONOMIC NERVOUS SYSTEM DYSFUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE ON DIALYSIS
- SIMULTANEOUS DUAL MYOCARDIAL IMAGING WITH I-123 BMIPP AND TL-201 IN PATIENTS WITH CORONARY HEART DISEASE
- MYOCARDIAL CARNITINE LEVELS IN PATIENTS WITH CHRONIC HEART FAILURE : Heart Failure : 46th Annual Scientific Meeting, Japanese Circulation Society
- SEPTAL Q WAVE IN EXERCISE TESTING : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Exercise Test
- Peak Systolic Blood Pressure in Exercise Testing is Associated With Scintigraphic Severity of Myocardial Ischemia in Patients With Exercise-Induced ST-Segment Depression
- EFFECTS OF COENZYME Q10 ON EXERCISE TOLERANCE IN CHRONIC STABLE ANGINA : Vasodilators, Hemodialysis : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Decreased Creatine Kinase Kinetics in Diabetic Cardiomyopathy
- PROTECTIVE EFFECTS OF γ-GLUTAMYLCYSTEINE ETHYL ESTER ON FREE RADICAL DAMAGE
- DECREASE IN Ca^ SENSITIVITY OF CARDIAC TROPONIN DUE TO OXYGEN FREE RADICALS
- ^P-NMR MAGNETIZATION TRANSFER STUDY OF HIGH-ENERGY PHOSPHATE METABOLISM IN STUNNED MYOCARDIUM
- Arrhythmogenic Effects of Arsenic Trioxide in Patients With Acute Promyelocytic Leukemia and an Electrophysiological Study in Isolated Guinea Pig Papillary Muscles
- A case of proteinase 3-antineutrophil cytoplasmic antibody-positive Sjogren's syndrome complicated with interstitial nephritis
- CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-kappa B p50 in cultured salivary gland epithelial cells from patients with Sjogren's syndrome
- EFFECTS OF HYDROGEN PEROXIDE ON STIMULATORY GUANINE NUCLEOTIDE-BINDING PROTEIN IN RAT HEART
- Stunned Myocardium and Oxygen Free Radicals : Sarcolemmal membrane damage due to oxygen free radicals : 54th Annual Scientific Session of the Japanese Circulation Society
- -0070-CARDIAC GS ACTIVITY OF CARDIOMUOPATHIC SYRIAN HAMSTER BIO 14.6
- -P222- LIPID PEROXIDE LEVEL AND GLUTATHIONE PEROXIDASE ACTIVITY IN THE HEART OF CARDIOMYOPATHIC HAMSTER BIO 14.6
- -P191- ROLE OF FREE RADICALS IN THE CARDIOMYOPATHIC SYRIAN HAMSTER BIO14.6
- -353-THE ROLE OF CARDIAC ADRENERGIC RECEPTORS IN CARDIOMYOPATHIC BIO 14.6 SYRIAN HAMSTERS
- DIURNAL VARIATION OF VENTRICULAR PREMATURE BEATS AND URINARY CATECHOLAMINES : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- PJ-593 Carotid Intima-media Thickness Can Predict Coronary Artery Disease Better Than Brachial-ankle Pulse Wave Velocity(Angina pectoris, basic/clinical-5 (IHD) PJ100,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- Usefulness of Delayed Enhancement Magnetic Resonance Imaging for Detecting Cardiac Rupture Caused by Small Myocardial Infarction in a Case of Cardiac Tamponade
- Different Actions of Cardioprotective Agents on Mitochondrial Ca^ Regulation in a Ca^ Paradox-Induced Ca^ Overload
- Modification of SR Ca^ Release by FK506 Induces Defective Excitation-Contraction Coupling Only When SR Ca^ Recycling is Disturbed (Cardiovascular Pharmacology, Basic/Clinical 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation So
- Left Ventricular Pseudo-False Aneurysm Detected With ECG-Gated Multidetector Computed Tomography and Cardiac Magnetic Resonance Imaging
- Usefulness of Stress Myocardial Perfusion Imaging for Evaluating Asymptomatic Patients After Coronary Stent Implantation
- SIMULTANEOUS DUAL MYOCARDIAL IMAGING WITH IODINE-123-β-METHYL IODOPHENYL-PENTADECANOIC ACID (BMIPP) AND THALLIUM-201 IN PATIENTS WITH CORONARY HEART DISEASE
- The Usefulness of Delayed Enhancement Magnetic Resonance Imaging for Diagnosis of Cardiac Sarcoidosis (Cardiomyopathy, Clinical 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Differential Diagnosis of Dilated Phase of Hypertrophic Cardiomyopathy by Using Delayed Enhancement Magnetic Resonance Imaging (DE-MRI)(Cardiomyopathy, Clinical 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Intracoronary Administration of Acetylcholine Directly Modifies ST-T Waves (ECG/Body Surface Potential Mapping/Holter 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Discordance Between Myocardial Perfusion Imaging SPECT (MPI) and Pressure Wire-derived Fractional Flow Reserve (FFRmyo) in Intermediate Coronary Stenoses(Nuclear Cardiology 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Non-genomic Effects of Aldosterone on Intracellular Na^+ Concentration in Rat Ventricular Myocytes : Analysis Using Sodium-green With Laser Scanning Confocal Microscopy(Neurohumoral Factors 3 (H), The 69th Annual Scientific Meeting of the Japanese Circula
- A Selective Inhibitor of Na^+/Ca^ Exchanger, SEA0400, Preserves Cardiac Function and High-energy Phosphates Against Ischemia/reperfusion Injury(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circu
- Direct Effects of Protein Kinase A on Mitochondrial Membrane Potential and Redox State are Mediated by Reactive Oxygen Species(ROS)(Metabolism/Biochemistry/Energetics 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Post-challenge Hyperinsulinemia Rather Than Hyperglycemia is Associated with the Severity of Coronary Artery Disease in Non-diabetic Patients(Diabetes/Obesity 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Opening of Mitochondrial Permeability Transition Pore by Reactive Oxygen Species Protects Myocardium from Ischemia/Reperfusion Injury(Myocardial Ischemia-reperfusion, Basic 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-498 The Arrhythmogenic Effects of Arsenate in Patients with Acute Promyelocytic Leukemia and Electrophysiological Study in Guinea Pig Papillary Muscles(Arrhythmia, Basic 5 (A) : PJ83)(Poster Session (Japanese))
- PJ-383 The Mitochondrial Ca Accumulation is Necessary for Cell Protection by Ca Preconditioning(Metabolism/Biochemistry/Energetics 2 (IHD) : PJ64)(Poster Session (Japanese))
- Effects of Mg^ on Ca^ waves and Ca^ transients of rat ventricular myocytes
- DUAL-TRACER AUTORADIOGRAPHY WITH THALLIUM-201 AND IODINE-125 MIBG IN BIO 14.6 CARDIOMYOPATHIC SYRIAN HAMSTERS
- A ROLE OF MYOCARDIAL β-ADRENOCEPTOR ON DEVELOPMENT OF CARDIOMYOPATHY IN CARDIOMYOPATHIC SYRIAN HAMSTER BIO 14.6
- THE EFFECTS OF HIGH Mg^ SOLUTION ON "Ca^ WAVE" AND [Mg^]IN ISOLATED RAT VENTRICULAR CELLS
- ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFEDTS OF VERAPAMIL DURING CORONARY ARTERY REPERFUSION
- Ca^ TRANSIENTS AND CELL SHORTENING IN DIABETIC RAT VENTRICULAR MYOCYTES
- EFFECTS OF PHOSPHOLIPASE C ON ACTION POTENTIALS AND INTRACELLULAR Ca^ CONCENTRATION IN GUINEA PIG HEART
- -1173-DIFFUSE SLOW WASHOUT IN EXERCISE Tl-201 EMISSION COMPUTED TOMOGRAPHY : EVALUATION IN PATIENTS WITH PROIR MYOCARDIAL INFARCTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SILENT MYOCARDIAL ISCHEMIA IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION : EVALUATION BY EXERCISE THALLIUM-201 EMISSION COMPUTED TOMOGRAPHY : Ischemic Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- -1283-Ca^ WAVE AND INTRACELLULAR Ca^ CONCENTRATION IN RAT AND GUINEA PIG VENTRICULAR MYOCYTES : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0881-INTRACELLULAR Ca^ CONCENTRATION AND pHi IN CELL INJURY DURING METABOLIC INHIBITION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EXERCISE-INDUCED SILENT MYOCARDIAL ISCHEMIA (Ex-SMI) : EVALUATION BY EXERCISE Tl-201 EMISSION COMPUTED TOMOGRAPHY (Ex-ECT) : RI : 53 Annual Scientific Meeting, Japanese Circulation Society
- POOR R WAVE PROGRESSION (PRWP) IN THE RIGHT PRECORDIAL LEADS : EVALUATION BY EXERCISE Tl-201 EMISSION COMPUTED TOMOGRAPHY (ECT) : ECG, VCG, Mapping : 53 Annual Scientific Meeting, Japanese Circulation Society
- Wolff-Parkinson-White Syndrome with Gradual Transition from Type A to Type B
- Does Remodeling of Gap Junctions and Connexin Expression Contribute to Arrhythmogenesis? : Study in an Immobilization Rat Model
- ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFECTS OF VERAPAMIL DURING CORONARY OCCLUSION AND REPERFUSION : Arrhythmias (I), Electrophysiology (II) : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- L-Carnitine Treatment for Congestive Heart Failure : Experimental and clinical study : CURRENT THERAPY OF INTRACTABLE HEART FAILURE
- MYOCARDIAL FREE CARNITINE AND FATTY ACYLCARNITINE LEVELS IN PATIENTS WITH CHRONIC HEART FAILURE
- ARRHYTHMIA AFTER THE RELEASE OF INHIBITED OXIDATIVE PHOSPHORYLATION : The 53th Annual Scientific Session of the Japanese Circulation Society
- Oxygen-derived Free Radicals Related Injury in the Heart During Ischemia and Reperfusion : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research
- STUDY OF Ca^ OVERLOAD IN MYOCARDIAL ISCHEMIA AND REPERFUSION : CELL MORPHOLOGY AND INTRACELLULAR Ca^ CONCENTRATION MEASURED BY FURA-2 : Pathophysiology : 53 Annual Scientific Meeting, Japanese Circulation Society
- EFFECTS OF ACTIVE OXYGEN ON ARRHYTHMOGENESIS AND INTRACELLULAR Ca^ CONCENTRATION : EFFECTS OF HYDROGEN PEROXIDE : Arrhythmias : 53 Annual Scientific Meeting, Japanese Circulation Society
- -177-EFFECTS OF STROPHANTHIDIN ON INTRACELLULAR CALCIUM CONCENTRATION AND SPONTANEOUS CONTRACTION : Cardiac Metabolism, Cardiac Biochemistry : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -P188- CARDIAC ADRENOCEPTORS AND CALCIUM ANTAGONIST RECEPTOR IN CARDIOMYOPATHIC SYRIAN HAMSTER BEFORE THE ONSET OF CARDIAC NECROSIS
- -0424-SYMPATHETIC INNERVATION OF THE HEART IN CARDIOMYOPATHIC HAMSTER BIO14.6 : AUTORADIOGRAPHIC STUDY WITH ^I-MIBG
- ROLE OF_ -ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6
- EFFECTS OF L-CARNITINE ON TISSUE LEVELS OF ACYL CARNITINE, ACYL COA AND ADENOSINE TRI-PHOSPHATE IN ISCHEMIC DOG HEATS : Myocardial metabolism Biochemistry : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- STUDIES ON ARRHYTHMOGENESIS OF HIGH FREE FATTY ACIDS IN ISCHEMIC HEART DISEASE : ROLE OF LONG CHAIN ACYL COA AND LONG CHAIN ACYL CARNITINE : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- STUDIES ON ANTIARRHYTHMIC EFFECTS OF L-CARNITINE (REPORT 3): : EFFECTS OF L-CARNITINE ON HEMODIALYSIS ARRHYTHMIAS : Cardiovascular Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Effect of High Plasma Free Fatty Acids on the Free Radical Formation of Myocardial Mitochondria Isolated from Ischemic Dog Hearts
- Effects of L-Carnitine on Arrhythmias during Hemodialysis
- DEVELOPMENT OF A NEW ACTIVITY-INPUT-TYPE AMBULATORY ELECTROCARDIOGRAM AND ITS CLINICAL USEFULNESS
- Effect of Nitroglycerin on the Free Radical Formation of Myocardial Mitochondria Impaired by Ethanol : Studies by Electron Spin Resonance (ESR) Spectrometry
- Carnitine Distribution in Subepicardial and Subendocardial Regions in Normal and Ischemic Dog Hearts
- Effect of L-Carnitine on Cardiac Hernodynamics
- Effects of L-carnitine on phospholipids in the ischemic myocardium.
- Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris.
- Effects of L-carnitine on action potential of canine papillary muscle impaired by long chain acyl carnitine.
- Effects of Nitroglycerin on Left Ventricular Function in Patients with Ischemic Heart Disease
- Changes in the Subcellular Distribution of Free Carnitine and Its Acyl Derivatives in Diabetic Rat Hearts Following Treatment with L-Carnitine
- Intracellular Sodium Concentration in Diabetic Rat Ventricular Myocytes
- Effects of pantethine on action potential of canine papillary muscle during hypoxic perfusion.
- Unstable angina in a patient with mucocutaneous lymph node syndrome.
- Carnitine derivatives in hereditary cardiomyopathic animals.
- Possible Involvement of Free Radicals and Antioxidants in the Early Stages of the Development of Cardiomyopathy in BIO 14.6 Syrian Hamster.