NC-1300, a Proton-Pump Inhibitor, Requires Gastric Acid to Exert Cytoprotection in Rat Gastric Mucosa.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of gastric acid suppression on the cytoprotective effect of a single dose of NC-1300 given intragastrically was studied. NC-1300 given intragastrically prevented gastric mucosal damage caused by absolute ethanol in rats in a dose-related manner, while the drug given subcutaneously did not. Pretreatment with NC-1300 given subcutaneously to suppress acid secretion abolished the protective effect of NC1300 given intragastrically, but not in the presence of 0.1 N HC1. Repeated intragastric administration of NC-1300 for 7 days failed to prevent the ethanol damage. These results suggest that NC-1300 requires gastric acid to exert a protective effect against ethanol in rat gastric mucosa.
- 公益社団法人 日本薬理学会の論文
著者
-
ARAKAWA TETSUO
Third Department of Internal Medicine, Osaka City University Medical School
-
HIGUCHI KAZUHIDE
Third Department of Internal Medicine, Osaka City University Medical School
-
Arakawa Tetsuo
Third Department Of Internal Medicine Osaka City University Medical School
-
Satoh Hiroshi
Third Department Of Internal Medicine
-
Kobayashi Kenzo
Third Department Of Internal Medicine And The Department Of Biochemistry And Anatomy Osaka City Univ
-
FUKUDA Takashi
Third Department of Internal Medicine Osaka City University Medical School
-
Fukuda Takashi
Third Department of Internal Medicine, Osaka City University Medical School
-
Koike Kazunari
Third Department of Internal Medicine, Osaka City University Medical School
関連論文
- 0168 THE ROLE OF GLYCOLYSIS AND OXIDATIVE PHOSPHORYLATION IN THE REGULATION OF Na^+-H^+ EXCHANGE-STUDY USING ISOLATED VENTRICULAR MYOCYTES
- -0938- THE CHANGES IN[Na^+]i DURING METABOLIC INHIBITION : THE ROLES OF Na^+/H^+ EXCHANGE AND THE Na^+/K^+ PUMP IN THE REGULATION OF[Na^+]i(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Helicobacter pylori : criminal or innocent bystander?
- Effect of culture conditions on morphological changes of Helicobacter pylori
- A case of primary Hodgkin's desease of the stomach
- 0144 QUANTIFICATION OF CAPACITANCE-VOLUME RATIO AND Ca^ FLUX IN CARDIAC MYOCYTES WITH LASER CONFOCAL MICROSCOPY AND WHOLE CELL PATCH-CLAMP TECHNIQUE
- Action of endothelins on hepatic stellate cells
- Primary biliary cirrhosis complicated by severe hypoxemia
- PJ-593 Carotid Intima-media Thickness Can Predict Coronary Artery Disease Better Than Brachial-ankle Pulse Wave Velocity(Angina pectoris, basic/clinical-5 (IHD) PJ100,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- Evaluation of portal circulation through the superior mesenteric vein with an enteric capsule of [^I]iodoamphetamine
- Marked Enhancement by Fish Meal of Helicobacter pylori-induced Gastritis in Mongolian Gerbils
- Corticosteroids for the management of ulcerative colitis
- DECREASE IN GASTRIC MUCOSAL DEFENSE MECHANISMS AFTER LONG-TERM TREATMENT WITH AN ANTIULCER DRUG, CIMETIDINE, AND POSSIBLE ROLE OF ENDOGENOUS PROSTAGLANDINS IN GASTRIC MUCOSAL ADAPTATION
- Double-blind comparative study of sulfasalazine and controlled-release mesalazine tablets in the treatment of active ulcerative colitis
- The Effect of Free Radical on Prostaglandin Synthesis in Cultured Rat Gastric Mucosal Cells
- New Aspects of Gastric Adaptive Relaxation, Reflex after Food Intake for More Food : Involvement of Capsaicin-sensitive Sensory Nerves and Nitric Oxide
- Intracellular Sodium Concentration in Diabetic Rat Ventricular Myocytes
- NC-1300, a Proton-Pump Inhibitor, Requires Gastric Acid to Exert Cytoprotection in Rat Gastric Mucosa.