GA-56の一般薬理学的研究 (Pseudomonas属菌産生脂質分解酵素GA-56の薬理学的研究-1,2-)

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This paper describes an experimental study of effects of GA-56 on the central nervous system, respiratory and circulatory system, smooth muscle and urinary volume, 1) GA-56 did not effect the central nervous system, such as was seen regarding the sleeping time of hexobalbital, convulsions of strychnine, pain sensation and body temperature. 2) GA-56 revealed little effect on the respiratory and circulatory system, such as respiration, blood pressure, electrocardiogram, isolated atrial, isolated heart, whole heart, peripheral blood vessels. 3) GA-56 showed no remarkable effect on smooth muscle, such as isolated intestine of guinea-pig and rabbit and whole intestine of rabbit. GA-56 did not effect on the urinary volume. By way of summarization, it has been demonstrated that GA-56 is a safe drug provided it is administrated orally.
社団法人日本薬理学会の論文