ヒ素代謝に関する研究 : (第4報)ヒ素に対する耐容性の発生におよぼす飼料の影響について

概要

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Experiments were carried out to ascertain the effect of milk food (whole milk powder 80%, dextrin 20%) and cereal food (only cereal) to which arsenite had been added on the absorption of the arsenite from the digestive tract (residues in feces and excretion in urine) as well as accumulation in the organs. 1) The arsenite had a tendency to remain in the feces, the quantity gradually increasing. By the fifth week, the arsenite had been excreted approx. 50 percent in the case of cereal and 100 percent in the case of milk. 2) With milk, the quantity of arsenite in the brain and liver did not increase after the second week in whole organ and per g of organ, while the quantity in the kidney increased a little in whole organ, but did not increase per g. In the spleen, the quantity increased a little in whole organ and per g of organ. With cereal, the quantity in the brain, liver and kidney increased in whole organ and per g of organ, while in the spleen the increase was little. In the fifth week quantity in the brain, liver, kidney and spleen of rats raised on milk was relatively little as compared with those on cereal. 3) When rats were raised on arsenite added food, occurrence of arsenic tolerance in the digestive tract was recognized. Milk showed a considerable promotive effect to this occurrence of arsenic tolerance.
社団法人日本薬理学会の論文