ヒ素代謝に関する研究 : (第7報)飼料のヒ素添加量と臓器のヒ素含有量,とくに飼料のおよぼす影響について

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The experiment were carried out ascertain the added arsenite in diet and resulting content in each organ, as well as the effect on diet. 1) When rats were raised on an arsenite-added diet (1, 000 p. p. m.), the rats died in two weeks while on milk or cereal. There was little body weight gain in one week. When rats were raised on an arsenite-added diet (50 or 200 p. p. m.), there were no differences in body weight gain as compared with rats on a non-arseniteadded diet of milk or cereal. 2) A milk or cereal diet resulted in the same content in each rat organ when the rats had been raised on an arsenite-added diet (1, 000 p. p. m.) for one week. Regarding the whole organ, the order of arsenite content was: liver, kidney, spleen and brain. In organ per g the order was: spleen, kidney, liver and brain. The quantity of arsenite in the brain was little in either the whole organ or organ per g. 3) When rats were raised on an arsenite-added diet of 50, 200, 650 p. p. m. for 35 days, the content of arsenite in the whole organ was estimated as most in the liver, least in the brain. In the kidney and spleen a change was observed depending on the volume of arsenite and diet. The content of arsenite in organ per g was the highest in the spleen, next in the liver and lowest in the brain and kidney. When rats were raised on cereal rather than milk the content in each organ greater. 4) The increase of added arsenite corresponded to the increased amount of arsenite in each organ.
社団法人日本薬理学会の論文

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野崎茂
東京歯科大学薬理学教室

ヒ素代謝に関する研究 : (第7報)飼料のヒ素添加量と臓器のヒ素含有量,とくに飼料のおよぼす影響について

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