GA-56の慢性毒性実験 (Pseudomonas属菌産生脂質分解酵素GA-56の薬理学的研究-3〜5-)

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Results are as follows : 1) There were no changes in body weight gain of rats with administration of 4, 000 mg/kg and 10, 000 mg/kg of GA-56, but gain in body weight of rats on 25, 000 mg/kg for 26 weeks, decreased. 2) There were no changes in RBC, WBC, Hgb, Ht and hemmogramm. 3) There was no prolongation of bleeding time and no delayed action in coagulation time. 4) There were no changes in liver function, blood sugar and serum protein content, and natrium ion and potassium ion in serum. 5) Urobilinogen, bilirubin and occult blood counts in urine of rats were all negative. 6) A difference in organ weight was observed in the 25, 000 mg/kg group, but not so in the 4, 000 mg/kg group and the 10, 000 mg/kg group as compared to the control. 7) There were no pathological changes in any organ of rats on a large dose of GA-56.
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