ヒ素代謝に関する研究(第5報) : ヒ素とBlood BrainBarrier,とくに飼料のおよぼす影響について

概要

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These experiments were done to ascertain the function of the blood brain barrier utilizing dyes Bromphenol Blue and Evans Blue. 1) In rats fed arsenite-added 1000 p. p. m. milk and cereal for 7 days, half of the rats died, however the blood brain barrier was normal, and the brains were not colored by either dye. 2) In rats fed arsenite-added 650 p. p. m. milk and cereal for 14 days, all rats were healthy, the blood brain barrier was normal and the brains were not colored by either dye. 3) In rats fed arsenite-added 650 p. p. m. milk and cereal for 35 days, few rats died. In the case of milk fed rats the blood brain barrier was normal and the brains not colored by either dye, but in the cereal fed rats all were abnormal and the brains were colored by Bromphenol Blue, but not by Evans Blue. 4) Milk appears to be more protective for the brain than cereal.
社団法人日本薬理学会の論文