Clinicopathological Study on Hepatitis C Virus-associated Glomerulonephritis without Hepatitis C Virus in the Blood
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概要
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Purpose Patients with hepatitis C virus (HCV)-associated glomerulonephritis in whom HCV RNA was not detected in the blood have been reported. We attempted to uncover the differences between HCV RNA-negative and HCV RNA-positive cases. Methods The clinical and pathological findings for 5 patients with HCV-associated glomerulonephritis without HCV in the blood were compared with those for 23 patients with HCV RNA-positive HCV-associated glomerulonephritis. Results The HCV RNA-negative cases were characterized by advanced age, female dominance, no cryoglobulinemia and no glomerular deposition of IgG compared with the HCV RNA-positive cases, although no differences were observed in amount of urinary protein, frequency of nephrotic syndrome, serum levels of total protein, creatinine level, presence of hypocomplementemia and rheumatoid factor. The prognosis was similar for both groups. Conclusion These cases point to the need for further study of the pathogenesis of this disease.
著者
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Murakami Reiichi
Department Of Cardiology Nephrology Respiratory Medicine Hirosaki University School Of Medicine
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Nakamura Norio
Department Of Anatomy Gunma University School Of Medicine
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Fujita Takeshi
Department Of Applied Physics Osaka City University
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Yamabe Hideaki
Department of Nephrology, Graduate School of Medicine, Hirosaki University
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Shimaya Yuko
Department of Nephrology, Graduate School of Medicine, Hirosaki University
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Shimada Michiko
Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine
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Shimada Michiko
Department of Nephrology, Hirosaki University Graduate School of Medicine
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Nakamura Norio
Department of Nephrology, Hirosaki University Graduate School of Medicine
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Kitajima Maiko
Hirosaki University Graduate School of Health Sciences
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Urushizaka Mayumi
Hirosaki University Graduate School of Health Sciences
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