Role of the Steady - State Na^+ Channel Current in Pacemaker Depolarizations in Young Embryonic Chick Ventricular Myocytes
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概要
- 論文の詳細を見る
To assess the age-related changes in kinetic properties of the cardiac Na<SUP>+</SUP> channel, whole-cell voltage-clamp (v-c) experiments were conducted using 3-, 10- and 17-day-old embryonic chick ventricular heart cells. In line with the first-order kinetic model, kinetic parameters for the activation and inactivation of the channel were determined from the v-c results. Simulation studies using kinetic parameters so determined have reproduced the current-voltage relations and the steady-state inactivation characteristics observed in cells in the three age groups. The rate of depolarization of the simulated action potentials was also comparable to that experimentally recorded. In conclusion, the steady-state Na<SUP>+</SUP> conductance can play a significant role in the automatic depolarizations observed in young embryonic ventricular cells.
- 社団法人 日本薬理学会の論文
- 1995-10-01
著者
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FUJITA Takeshi
Department of Dental and Biomedical Materials Science, Unit of Basic Medical Sciences, Graduate Scho
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Ebina Yoshio
Department Of Electric Engineering Faculty Of Engineering Yamaguchi University
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SPERELAKIS Nicholas
Department of Molecular and Cellular Physiology, College of Medicine, University of Cincinnati
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Ban Takashi
Department Of Pharmacology School Of Medicine Yamaguchi University
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Ban Takashi
Department Of Pharmacology Faculty Of Medicine Kyoto University
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SADA Hideaki
Department of Pharmacology, School of Medicine, Yamaguchi University
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Sada H
Department Of Pharmacology School Of Medicine Yamaguchi University
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Sperelakis N
Univ. Cincinnati Ohio Usa
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Sperelakis Nicholas
Department Of Molecular And Cellular Physiology College Of Medicine University Of Cincinnati
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Fujita Takeshi
Department Of Dental And Biomedical Materials Science Unit Of Basic Medical Science Graduate School
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Fujita Takeshi
Department Of Applied Physics Osaka City University
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Fujita Takeshi
Department Of Electric Engineering Faculty Of Engineering Yamaguchi University
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