Action Potential Duration-Stabilizing Action of Taurien in Guinea Pig Ventricular Myocytes

概要

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To examine taurine actions on the rate of repolarization of action potentials (AP), L-type Ca2+ (Ica), late outward K+ (IK) and the inward rectifier currents as affected by the external Ca2+ concentrations ([Ca2+]o), whole-cell voltage-clamp and current-clamp experiments were conducted in guinea pig ventricular myocytes. At a high (3.6 mM) [Ca2+]o, 10 mM taurine suppressed both Ica and IK, shortened AP duration and decelerated the rate (−dV/dt) of terminal repolarization of AP. In contrast, at a low (0.9 mM) [Ca2+]o, taurine intensified both Ica and IK, lengthened AP duration and accelerated −dV/dt. However, at either [Ca2+]o, the resting membrane potential was slightly hyperpolarized, and the inward rectifier current examined by the ramp-pulse protocol remained unaffected by taurine. Taurine is suggested to maintain a stable AP duration by altering the inward Ca2+ and IK in the opposite directions, depending on [Ca2+]o. The relevance of the stabilizing action of taurine on the AP duration to its reported antiarrhythmic efficacies is discussed.
社団法人日本薬理学会の論文
1996-04-01