8, THE EFFECT OF CHLORPROMAZINE OF THE AFFERENT PAPHWAYS OF THE HIPPOCAMPUS

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1. The effects of chlorpromazine on the afferent and efferent pathways of the hippocampus were investigated and compared with that of hexobarbital sodium.2. Chlorpromazine and hexobarbital sodium suppressed the hippocampal seizures induced by repetitive stimulation of the fornix.3. Single shock response or post-tetanic potentiation recorded from the hippocampus following single or repetitive stimulation of the fornix were not depressed by chlorpromazine.Hexobarbital sodium suppressed the development of potentiation without any effect on single shock potential in this pathway.4. Chlorpromazine and hexobarbital sodium selectively depressed posttetanic potentiation following reptitive stimulation of amygdala without affecting single shock potential.5. Effects of these drugs on the efferent pathway from the hippocampus to hypothalamus were investigated. Chlorpromazine had no significant effects on this pathway. Hexobarbital sodium suppressed the development of potentiation of the hypothalamic response following repetitive stimulation of the hippocampus without notable effect on single shock response.
日本脳神経外科学会の論文