Zeolite 4A, a Synthetic Silicate, Suppresses Melanogenesis through the Degradation of Microphthalmia-Associated Transcription Factor by Extracellular Signal-Regulated Kinase Activation in B16F10 Melanoma Cells
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概要
- 論文の詳細を見る
Zeolite 4A, synthetic silicate, has been shown to exhibit diverse biological activities such as anti-cancer and anti-oxidant activity. In the present study, we report that the zeolite 4A may improve skin-whitening. We found that zeolite 4A inhibited melanin production in a dose-dependent manner, which has not cytotoxicity. Zeolite 4A also inhibited alpha-melanocyte-stimulating hormone (α-MSH)-induced melanin synthesis in B16F10 cells. Interestingly, zeolite 4A decreased α-MSH-induced tyrosinase activity in B16F10 cells, which did not inhibit tyrosinase activity under cell-free conditions. The results of this study indicate that zeolite 4A may reduce pigmentation by way of an indirect nonenzymatic mechanism. We also found that zeolite 4A decreased α-MSH-induced microphthalmia-associated transcription factor (MITF) and tyrosinase expression and that zeolite 4A induced the activation of extracellular signal-regulated kinase (ERK). These results suggest that the depigmenting effect of zeolite 4A may result from the down-regulation of MITF and tyrosinase expression by increasing ERK activity. The results thus provide evidence that zeolite 4A can be used as a potential skin-whitening agent.
- 公益社団法人 日本薬学会の論文
著者
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Han Chang-soo
Department Of Mechanical Engineering Hanyang University
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Shin Yong
Department Of Anesthesiology And Pain Medicine Chungnam National University Hospital
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Ko Seong-gyu
Laboratory Of Clinical Biology And Pharmacogenomics College Of Oriental Medicine Kyunghee University
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Chung Myung-hee
Department Of Pharmacology Seoul National University College Of Medicine
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Ye Sang-kyu
Department Of Pharmacology College Of Medicine Seoul National University
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Shin Jong
Department Of Automotive Service Tonghae University
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Lee Chang
Departlnent Of Biology College Of Natural Sciences Kyungpook National University Korea
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Shin Jong
Department of Internal Medicine, Chung Ang University College of Medicine
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Kim Hong-Sook
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Ko Seong-Hee
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Hwang Seung
Greenjui
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Ye Sang-Kyu
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Han Chang-Soo
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Chung Myung-Hee
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Ko Seong-Gyu
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
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Shin Yong
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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Lee Chang
Department of Pharmacology and Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University
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