Squalene as a Target Molecule in Skin Hyperpigmentation Caused by Singlet Oxygen
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概要
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Based on our previous finding (Biochem. Biophys. Res. Commun., 223, 578—582, 1996) of singlet oxygen generation from coproporphyrin excreted on the skin surface from Propionibacterium acnes, we hypothesized that singlet oxygen formed in this way under UV exposure would promote peroxidation of skin surface lipids. We found that squalene was oxidized efficiently by singlet oxygen derived from coproporphyrin under UV exposure, and that the rate constant of squalene peroxidation by singlet oxygen was ten-fold higher than that of other skin surface lipids examined. The reaction was promoted more efficiently by UVA than by UVB. Furthermore, we found that topical application of squalene peroxide induced skin hyperpigmentation through increasing prostaglandin E2 release from keratinocytes in guinea pigs. These results suggest that squalene peroxide formation by singlet oxygen plays a key role in photo-induced skin damage.
著者
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ARAI Hiroyuki
Department of Biotechnology, The University of Tokyo
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荒金 久美
Research Laboratory Kose Corporation
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NAGANO Tetsuo
Laboratory of Bioorganic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The Un
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RYU Akemi
Research Laboratory, KOSE Corporation
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ARAKANE Kumi
Research Laboratory, KOSE Corporation
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Koide Chiharu
Research & Development Division, KOSÉ Corporation
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Arai Hiroyuki
Department Of Biotechnology The University Of Tokyo
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Arai Hiroyuki
Department Of Applied Chemistry Tokai University
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Ryu Akemi
Research Laboratories, KOSÉ Corporation
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Nagano Tetsuo
Laboratory of Chemistry and Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Arakane Kumi
Research Laboratories, KOSÉ Corporation
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