Risk of Falls in Alzheimer's Disease : A Prospective Study
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概要
- 論文の詳細を見る
Objective Falls are common in patients with Alzheimer’s disease (AD). Identification of the potential risk factors and developing preventive strategies for falls will have a significant impact in maintaining the quality of life in AD.Patients Clinical follow-up of 124 (74.1±6.1 years, range 62-88) mild to moderate AD patients in an outpatient memory clinic.Methods Postural sway, cognitive function, use of neuroleptics, severity of periventricular and deep white matter lesions, and the presence or absence of silent brain infarctions on magnetic resonance imaging were assessed at baseline.Results A total of 104 patients (84%) completed the study. Fall events were confirmed in 42.3% (44/104). After adjustment for age, gender, and cognitive status, a high grade of periventricular white matter lesions (odds ratio 8.7 [95%CI 1.5 to 51.8], p=0.017) and neuroleptic drug use (odds ratio 3.5 [95%CI 1.2 to 10.5], p=0.027) were significantly associated with an increased risk of falls.Conclusion Our results suggest that periventricular white matter lesions and the use of neuroleptics may be related to falls in mild to moderate AD. A comprehensive risk management of brain ischemia as well as the use of the smallest efficacious dose of neuroleptics in the treatment of behavioral and psychiatric symptoms of AD should be recommended to help reduce the risk of unexpected falls.
- 社団法人 日本内科学会の論文
- 2005-07-01
著者
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ARAI Hiroyuki
Department of Biotechnology, The University of Tokyo
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佐々木 英忠
東北大学第一内科
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佐々木 英忠
秋田看護福祉大学
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佐々木 英忠
東北大学 大学院 内科病態
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佐々木 英忠
東北大医老人科
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Seki Takashi
Department ot Pediatrics, Nippon Medical School
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佐々木 英忠
東北大学医学部
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Akatsu H
Center For Asian Traditional Medicine Department Of Geriatrics And Gerontology Tohoku University Gra
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Arai Hiroyuki
東北大学 医学系研究科老年病態学
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佐々木 英忠
東北大学老年科
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SUEMOTO Takahiro
BF Research Institute
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SASAKI Hidetada
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine
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MATSUI Toshifumi
Department of Geriatrics and Gerontology, Tohoku University Graduate School of Medicine
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IWASAKI Koh
Department of Geriatric and Complementary Medicine, Center for Asian Traditional Medicine Research
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HORIKAWA Etsuo
Division of Physical and Behavioral Support System, Center for Comprehensive Community Medicine, Fac
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Iwasaki Koh
Center For Asian Traditional Medicine Department Of Geriatrics And Gerontology Tohoku University Gra
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Iwasaki Koh
Department Of Physics Tokyo Institute Of Technology
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Matsui Toshifumi
Department Of Geriatrics And Gerontology Tohoku University Graduate School Of Medicine
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Matsui Toshifumi
東北大学 医学系研究科老年病態学
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Sasaki H
Department Of Geriatric And Respiratory Medicine Tohoku University School Of Medicine
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Sasaki Hidetada
東北大学 医学部老年呼吸器医療分野
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佐々木 英忠
東北大学 第一内科
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Horikawa Etsuo
Division Of Physical And Behavioral Support System Center For Comprehensive Community Medicine Facul
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Sasaki Hidetada
Department Of Geriatric And Respiratory Medicine Tohoku University Graduate School Of Medicine
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Seki Takashi
Department Ot Pediatrics Nippon Medical School
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Tsuboi Masahiro
Department Of Geriatrics And Gerontology Tohoku University Graduate School Of Medicine
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SASAKI Hidetada
Sendai Tomizawa Hospital
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Matsui Toshifumi
Department Of Geriatric And Respiratory Medicine Tohoku University School Of Medicine
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Iwasaki Koh
Department Of Biomedical Engineering Graduate School Of Medicine The University Of Tokyo
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Arai Hiroyuki
Department Of Biotechnology The University Of Tokyo
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Matsui Toshifumi
Department Of Geriatric And Respiratory Medicine Tohoku University Graduate School Of Medicine
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Seki Takashi
Department Of Geriatric And Complementary Medicine Center For Asian Traditional Medicine Research To
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Seki Takashi
Department Of Cardiology Sendai Medical Center
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Arai Hiroyuki
Department Of Applied Chemistry Tokai University
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