Retrospective Analyses of Clinical Features and Therapeutic Outcomes in Thymectomized Patients with Myasthenia Gravis at Shinshu University
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概要
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Objectives Thymectomy has become recognized as an integral element in the treatment of patients with myasthenia gravis (MG). Although the incidence of elderly-onset MG has recently been increasing, there is little data demonstrating the efficacy and complications of thymectomy in this population. To clarify this point, we divided the thymectomized patients with MG into young and elderly groups, and retrospectively examined their clinical features and therapeutic outcomes. Patients and Methods We reviewed 57 MG patients who had been admitted to our hospital between 1988 and 2002. The patients were classified into young (younger than 60) and elderly (60 or older) groups according to the age of onset, and the therapeutic outcomes of thymectomy were evaluated using myasthenic severity scales and the duration from operation to discharge. Results Myasthenic severity scales significantly improved after thymectomy in the elderly group both with (p<0.005) and without thymoma (p<0.05) compared with before. With regard to the duration from thymectomy to discharge, no significant difference could be found between the young and elderly groups, irrespective of associated thymoma. There were no serious complications during and after thymectomy in either the young or the elderly group. Conclusions Despite various possible complications due to aging, thymectomy should be actively considered also in the treatment of elderly MG patients because it can reliably and safely improve myasthenic symptoms in combination with immunosuppressive agents, including corticosteroid.
- 社団法人 日本内科学会の論文
- 2004-03-01
著者
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Morita Hiroshi
The Third Division Department Of Internal Medicine Osaka Medical College
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Ikeda Shu-ichi
The Third Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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NAKAMURA Akinori
Third Department of Medicine, Shinshu University School of Medicine
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DOHI(IIJIMA) Naoko
the Third Department of Medicine, Shinshu University School of Medicine
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SEKIJIMA Yoshiki
the Third Department of Medicine, Shinshu University School of Medicine
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NAKAMURA Akinori
the Third Department of Medicine, Shinshu University School of Medicine
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MATSUDA Masayuki
the Third Department of Medicine, Shinshu University School of Medicine
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HANIUDA Masayuki
the Second Department of Surgery, Shinshu University School of Medicine
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HASHIMOTO Takao
the Third Department of Medicine, Shinshu University School of Medicine
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Ikeda Shuichi
The Third Department Of Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
Third Department Of Medicine Shinshu University School Of Medicine
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Ikeda Shu-ichi
The Third Department Of Internal Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
The Department Of Neurology Saku Central Hospital
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Ikeda Shu-ichi
Department Of Neurology Shinshu University School Of Medicine
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Haniuda Masayuki
The Second Department Of Surgery Shinshu University
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Haniuda Masayuki
The Second Department Of Surgery Shinshu University School Of Medicine
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Sekijima Yoshiki
The Third Department Of Medicine Shinshu University School Of Medicine
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Shimojima Yoshio
Third Department Of Medicine Shinshu University School Of Medicine
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Hashimoto Takao
The Third Department Of Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
The Third Department Of Medicine Shinshu University School Of Medicine
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Ikeda Shu-ihci
Dep. Of Medicine (neurology And Rheumatology) Shinshu Univ. School Of Medicine
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Shimojima Yasuhiro
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Matsuda Masayuki
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Hashimoto Takao
Third Department Of Medicine Shinshu University School Of Medicine
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Hashimoto Takao
The Third Department Of Internal Medicine Shinshu University School Of Medicine
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Dohi-Iijima Naoko
the Third Department of Medicine, Shinshu University School of Medicine
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Ikeda Shu-ichi
Third Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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