Increase in Incidence of Elderly-onset Patients with Myasthenia Gravis in Nagano Prefecture, Japan
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概要
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Objectives In European countries and the United States the incidence of elderly-onset myasthenia gravis (MG) has recently been increasing. To investigate whether the incidence of the elderly-onset MG has increased in Nagano Prefecture of Japan, we divided the patients into young and elderly groups, and retrospectively examined their incidence.Patients and Methods On the basis of two-step questionnaires sent to hospitals and the patient list of the intractable disease registration system in Nagano Prefecture we studied 213 MG patients diagnosed between 1982 and 2001. This 20-year period was divided into 4 five-year terms, and the incidence of MG in young- (younger than 65) and elderly-onset (65 or older) groups was investigated separately for each term.Results The ratio of the elderly-onset group showed a significantly positive correlation with terms irrespective of associated thymoma (r=0.98, p<0.05). There was a significant difference in the mean onset age among the 4 terms (p<0.005). The standardized incidence of MG gradually increased in both young- and elderly-onset groups as well as in the whole age range. The elderly group showed a particularly high incidence in females (12.01/million/year) and in patients without thymoma (8.78/million/year) in the final five years.Conclusions We confirmed that the incidence of elderly-onset MG has recently been increasing in the Nagano Prefecture. Since the change of the age distribution in this district is almost identical to that of the whole country, the incidence of MG might have been increasing in Japan as a whole, particularly in the elderly population.
- 社団法人 日本内科学会の論文
- 2005-06-01
著者
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MATSUDA Masayuki
Third Department of Medicine, Shinshu University School of Medicine
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IKEDA Shu-ichi
Third Department of Medicine, Shinshu University School of Medicine
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MATSUZAWA Shigeyuki
Department of Pediatrics, Shinshu University School of Medicine
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TABATA Ken-ichi
Department of Urology, Kitasato University School of Medicine
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SEKIJIMA Yoshiki
Third Department of Medicine, Shinshu University School of Medicine
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Tabata Ken-ichi
The Department Of Neurology Saku Central Hospital
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Tabata Ken-ichi
Department Of Urology Kitasato University School Of Medicine
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DOHI IIJIMA
Third Department of Medicine, Shinshu University School of Medicine
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NAKAMURA Akinori
Third Department of Medicine, Shinshu University School of Medicine
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MORITA Hiroshi
Third Department of Medicine, Shinshu University School of Medicine
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SATO Shun-ichi
Department of Neurology, Nagano Red Cross Hospital
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YAHIKOZAWA Hiroyuki
Department of Neurology, Nagano Red Cross Hospital
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YANAGAWA Sohei
Department of Neurology, Iida Municipal Hospital
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Matsuda Masayuki
Third Department Of Medicine Shinshu University School Of Medicine
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Dohi Iijima
Third Department Of Medicine Shinshu University School Of Medicine
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Yanagawa Sohei
Department Of Neurology Iida Municipal Hospital
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Ikeda Shu-ichi
Third Department Of Medicine Shinshu University School Of Medicine
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Sato Shun-ichi
Department Of Neurology Nagano Red Cross Hospital
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Yahikozawa Hiroyuki
Department Of Neurology Nagano Red Cross Hospital
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Yahikozawa Hiroyuki
Department Of Medicine (neurology) Shinshu University School Of Medicine
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Matsuda Masayuki
The Department Of Neurology Saku Central Hospital
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Ikeda Shu-ichi
Department Of Neurology Shinshu University School Of Medicine
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Nakamura Akinori
Third Department Of Medicine Shinshu University School Of Medicine
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Sekijima Yoshiki
Third Department Of Medicine Shinshu University School Of Medicine
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Sekijima Yoshiki
The Third Department Of Medicine Shinshu University School Of Medicine
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Matsuzawa Shigeyuki
Department Of Pediatrics Shinshu University School Of Medicine
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Shimojima Yoshio
Third Department Of Medicine Shinshu University School Of Medicine
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Ikeda Shu-ihci
Dep. Of Medicine (neurology And Rheumatology) Shinshu Univ. School Of Medicine
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Shimojima Yasuhiro
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Ikeda Shu-ichi
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Matsuda Masayuki
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Sekijima Yoshiki
Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine
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Dohi-Iijima Naoko
Third Department of Medicine, Shinshu University School of Medicine
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Tabata Ken-ichi
Department of Neurology, Saku Central Hospital
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