Malignant Lymphoma Associated with Rheumatoid Arthritis, Developing Shortly after Initiation of Oral Methotrexate

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概要

• 論文の詳細を見る

• We report a patient with rheumatoid arthritis (RA) who developed malignant lymphoma of the diffuse large B-cell type in the right submandibular region shortly after initiation of oral methotrexate (MTX). Despite cessation of MTX, the lymphadenopathy did not regress, and only reached complete remission after 3 courses of CHOP therapy followed by irradiation. In this patient highly active RA itself was considered to be the main cause of malignant lymphoma, and MTX might have contributed to the development by modifying the immune system. When RA is highly active, MTX should be used carefully because of the possible development of malignant lymphoma as well as other serious complications.

• 社団法人　日本内科学会の論文
• 2004-02-01

著者

• MATSUDA Masayuki

  Third Department of Medicine, Shinshu University School of Medicine

• GONO Takahisa

  Third Department of Medicine, Shinshu University School of Medicine

• SHIMOJIMA Yasuhiro

  Third Department of Medicine, Shinshu University School of Medicine

• IKEDA Shu-ichi

  Third Department of Medicine, Shinshu University School of Medicine

• SHIKAMA Naoto

  Department of Radiology, Reconstructive Medicine and Tissue Engineering, Shinshu University School o

• YAMAMOTO Kanji

  Third Department of Medicine, Shinshu University School of Medicine

• HOSHI Kenichi

  Third Department of Medicine, Shinshu University School of Medicine

• TOKUDA Takahiko

  Third Department of Medicine, Shinshu University School of Medicine

• Ikeda Shuichi

  The Third Department Of Medicine Shinshu University School Of Medicine

• Matsuda Masayuki

  Third Department Of Medicine Shinshu University School Of Medicine

• Hoshi Kenichi

  Third Department Of Medicine Shinshu University School Of Medicine

• Shikama Naoto

  Department Of Radiology Shinshu University School Of Medicine

• Yamamoto Kanji

  Third Department Of Medicine Shinshu University School Of Medicine

• Ikeda Shu-ichi

  Third Department Of Medicine Shinshu University School Of Medicine

• Ikeda Shu-ichi

  Department Of Neurology Shinshu University School Of Medicine

• Yamamoto Kanji

  The Department Of Neurology Toyoshina Red-cross Hospital

• Sekijima Yoshiki

  The Third Department Of Medicine Shinshu University School Of Medicine

• Matsuda Masayuki

  The Third Department Of Medicine Shinshu University School Of Medicine

• Shimojima Yasuhiro

  Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine

• Ikeda Shu-ichi

  Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine

• Matsuda Masayuki

  Third Department Of Medicine (neurology And Rheumatology) Shinshu University School Of Medicine

• Tokuda Takahiko

  Third Department Of Medicine Shinshu University School Of Medicine

• Shikama Naoto

  Department Of Radiation Oncology Saku General Hospital

• Ikeda Shu-ichi

  Third Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine

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