Severe Depression as an Initial Symptom in an Elderly Patient with Acute Disseminated Encephalomyelitis.
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概要
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We report a 63-year-old man with acute disseminated encephalomyelitis (ADEM), initially showing depression for one and a half months but subsequently meningoencephalitis followed by acute-onset myelopathy. Neuroradiological examinations of the brain demonstrated no focal lesion causative for his depression, while cerebrospinal fluid revealed elevated levels of inflammatory cytokines in parallel with disease activity. Because depression is usually a rare initial symptom for patients with ADEM, an increased production of inflammatory cytokines in the central nervous system as well as age-related alterations of immune response might have played an important role in the development of depression in this elderly patient.(Internal Medicine 40: 1149-1153, 2001)
- 社団法人 日本内科学会の論文
著者
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MATSUDA Masayuki
Third Department of Medicine, Shinshu University School of Medicine
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Ikeda Shu-ichi
The Third Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
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Tabata Ken-ichi
The Department Of Neurology Saku Central Hospital
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MATSUDA Masayuki
The Department of Neurology, Saku Central Hospital
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MIKI Jun
The Department of Neurology, Saku Central Hospital
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Ikeda Shuichi
The Third Department Of Medicine Shinshu University School Of Medicine
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Miki Jun
The Department Of Neurology Saku Central Hospital
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Miki Jun
Department Of Pediatrics Shinshu University School Of Medicine
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Miki Jun
Materials And Processing Research Center Nkk Corporation
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Ikeda Shu-ichi
The Third Department Of Internal Medicine Shinshu University School Of Medicine
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Matsuda Masayuki
The Department Of Neurology Saku Central Hospital
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Ikeda Shu-ichi
Department Of Neurology Shinshu University School Of Medicine
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Miki Jun
Department Of Urotogy Jikei University School Of Medicine
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Matsuda Masayuki
The Department Of Hepato-gastroemerology Shizuoka General Hospital
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Miki Jun
Department Of Polymer Chemistry Graduate School Of Engineering Kyoto University
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