Clinical Utility of Evaluating Intracranial Artery Stenosis and Silent Brain Infarction to Predict the Presence of Subclinical Coronary Artery Disease in Ischemic Stroke Patients

スポンサーリンク

概要

• 論文の詳細を見る

• Objective We have recently reported the prevalence of subclinical cardiovascular diseases and the association between the presence of subclinical coronary artery disease (CAD) and vascular risk factors in ischemic stroke patients. The relationship between the presence of subclinical CAD and elements of brain ischemia including intracranial artery stenosis, silent brain infarction (SBI), and white matter lesions remains unclear. We determined the usefulness of elements of brain ischemia to predict the presence of subclinical CAD in ischemic stroke patients. Methods The study group comprised 100 patients with first-ever ischemic stroke who had no history of CAD. Intracranial artery stenosis on magnetic resonance angiography and SBI and white matter lesions on magnetic resonance imaging were investigated in comparison with CAD defined as ≥50% stenosis on coronary computed tomographic angiography. Results Thirty-six patients had subclinical CAD. Intracranial artery stenosis (78.1% vs 35.1%, p<0.0001) and SBI (69.4% vs 46.9%, p=0.03) were more prevalent in patients with subclinical CAD. Of the patients with both intracranial artery stenosis and SBI, 61% had subclinical CAD. Multiple regression analyses showed that the presence of subclinical CAD was independently associated with intracranial artery stenosis; <50% stenosis (OR 8.01 95%CI 2.02 to 31.9; p<0.01), ≥50% stenosis (OR 19.5 95%CI 2.77 to 137.4; p<0.01), and multiple SBI (OR 3.85 95%CI 1.23 to 12.0; p<0.05). Conclusion The evaluation of intracranial artery stenosis and SBI may be useful to identify ischemic stroke patients at high risk for subclinical CAD.

著者

• Hoshino Atsushi

  Department Of Cardiology Kyoto Prefectural University Of Medicine

• Kurata Hiroyuki

  Department Of Bioscience And Bioinformatics Kyushu Institute Of Technology

• Nakahara Yoshifumi

  Department Of Cardiology Saiseikai Shiga Hospital

• Enomoto Satoko

  Department Of Cardiovascular Medicine Nantan General Hospital

• Nakamura Takashi

  Department Of Cardiology Saiseikai Shiga Hospital

• Kawahito Hiroyuki

  Department Of Cardiology Saiseikai Shiga Hospital Imperial Gift Foundation Inc.

• Ijichi Toshiharu

  Department of Neurology, Saiseikai Shiga Hospital

関連論文

• 1P113 Backbone NMR assignment and hydrogen exchange of goat α-lactalbumin(3. Protein folding and misfolding (1),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• 1P101 The role of Ca^ in the folding of goat α-Lactalbumin(3. Protein folding and misfolding (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Use of maximum entropy principle with Lagrange multipliers extends the feasibility of elementary mode analysis(BIOINFORMATICS)
• Subacutely progressed extensive aortic dissection complicated with catheter-induced dissection in left main coronary artery
• PE-448 Hypoxia-Induced p53 Deteriorates Cardiac Energetics and Apoptotic Cell Death via TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator)(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Ja
• Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists
• Constitutively Active Mutant N111G of Angiotensin II Type 1 (AT_1) Receptor Induces Homologous Internalization Through Mediation of AT_1-Receptor Antagonist
• Coulomb Excitation of ^24Si
• Coulomb Dissociation of ^23Al
• Coulomb Excitation of ^Si
• Coulomb Dissociation of ^Al
• The Long-term Prognosis for New Lesions after De novo Percutaneous Coronary Intervention in Diabetic Patients (Angina Pectoris, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Factors that Affect the Long-tern Prognosis of Patients with Normal ^I-BMIPP SPECT Imaging(Nuclear Cardiology 2 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Assessment of Binding Affinity to 5-Hydroxytryptamine 2A (5-HT_) Receptor and Inverse Agonist Activity of Naftidrofuryl : Comparison With Those of Sarpogrelate
• Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO_2 by using sequential administration of ^O-labeled compounds
• PE-394 p53 and SCO2 (Synthesis of Cytochrome c Oxidase 2) Augment the Progression of Diabetic Cardiomyopathy(PE066,Diabetes 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
• Identification of New Isotopes ^Pd and ^Pd Produced by In-Flight Fission of 345 MeV/nucleon ^U : First Results from the RIKEN RI Beam Factory(Nuclear physics)
• Inelastic Scattering of ^12Be with ^4He
• Inelastic Scattering of ^Be with ^4He
• Study of the ^7Be (p,γ)^8B Reaction with the Coulomb Dissociation Method
• The Design and Performance of Multiwire Proportional Chambers for High Flux Beam Monitoring
• Maximum entropy decomposition of flux distribution at steady state to elementary modes(BIOINFORMATICS)
• Development of a New High-Speed Measuring System to Analyze the Dental Cast Form
• Increased Alkaloid Production in a Suspension Culture of Coffea arabica Cells Using an Adsorption Column for Product Removal
• Substitutional Doping of a-Si_xN_ : H : III-1: AMORPHOUS FILMS
• Wide Optical-Gap, Photoconductive a-Si_xN_: H
• Nucleation of Microcrystallites in Phosphorus-Doped Si: H Films
• A New Technique of Boron Doping in Si:H Films
• Long-term survivorship analysis of hip arthroplasty with vitallium mold cup
• A New Auto-micromanipulation System for Three Dimensional Microinjection Assisted by a Confocal Laser Scanning Microscope
• Mutation of Important Amino Acid Residue of Asp104Lys in Human β_1-Adrenergic Receptor Triggers Functional and Constitutive Inactivation(Pharmacology)
• Identification of a Key Amino Acid of the Human 5-HT_ Serotonin Receptor Important for Sarpogrelate Binding
• Selectivity of Sarpogrelate to the Recombinant Human 5-HT_ Receptors as Assessed by Molecular Pharmacology and Molecular Modeling
• Non-Contact Evaluation for Articular Cartilage Using Ultrasound
• Calibration of a DBF Receiving Array Antenna by Using a Reference Sequence for Systems in Power-Limited Channels
• Prevalence of Coronary Artery Disease in Japanese Patients With Cerebral Infarction : Impact of Metabolic Syndrome and Intracranial Large Artery Atherosclerosis
• PJ-223 Behavioral Monitoring in Life-style Intervention Can Predict Cardiovascular Events Independently of Major Biological Risk Factors in High-risk Hypertensive Patients(Hypertension, clinical-9 (H) PJ38,Poster Session (Japanese),The 70th Anniversary An
• Evaluation of Arterial Stenosis of the Lower Limbs by Pressure Measurement with Nitroglycerin Loading (Peripheral Circulation/Vascular Disease 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Change of Inflammatory Markers in Atrial Flutter Patients Treated with Catheter Ablation(Infection/Inflammation/Immunity 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Characterization of a Novel Na^+/H^+ Antiporter Gene InNHX2 and Comparison of InNHX2 with InNHX1, Which is Responsible for Blue Flower Coloration by Increasing the Vacuolar pH in the Japanese Morning Glory
• Severe erosive arthropathy requiring surgical treatments in systemic lupus erythematosus
• Development of General-Purpose Particle and Heavy Ion Transport Monte Carlo Code
• A Field-Theoretic Model of Macroscopic Quantum Nucleation
• MECHANISM OF CIRCULATORY COLLAPSE IN RATS WITH SPONTANEOUSLYOCCURING HYPERTRORHIC CARDIOMYOPATHY
• Peptic ulcer recurrence during maintenance therapy with H^2-receptor antagonist following first-line therapy with proton pump inhibitor
• Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II–Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan
• Amino Acids of the Human α_-Adrenergic Receptor Involved in Antagonist Binding
• Pharmacological and Molecular Characterization of Novel SWR-Compounds for β-Adrenergic Receptors as assessed by Molecular Modeling, Site-Directed Mutagenesis, Binding Affinity and Functional Activity
• Assessment of Affinity and Dissociation Ability of a Newly Synthesized 5-HT_2 Antagonist, AT-1015: Comparison With Other 5-HT_2 Antagonists
• DPJ-050 Comprehensive Cardiac Rehabilitation Improves Clinical Outcome in Patients with Acute Coronary Syndrome after Implantation of Drug-eluting Stents(DPJ09,Exercise Test/Cardiac Rehabilitation (H),Digital Poster Session (Japanese),The 73rd Annual Scie
• PJ-117 Combination of Carotid Arterial Wall Thickness and Stiffness Parameters Improves Prediction of Target Organ Damage in Patients with Essential Hypertension(Hypertension, Clinical 2 (H) : PJ20)(Poster Session (Japanese))
• Chiral Tetrakis(2-thienyl)methane Derivative : A Possible Precursor for Cryptochiral Tetraalkylmethanes
• Synthesis and Properties of a 1,3-Thiazole Extended p-Terphenoquinone. A New sp^2 Nitrogen Atom-Containing Terquinone Derivative
• 5H,13H-5,13a-[1',2']Benzenocyclopenta[rst]pentaphen-13-one : A New Triptycene Derivative with a Strained Structure
• Photochemical and Redox Switching in a Ring-closed Isomer of Thioindigo-extended Quinone
• 1,1,4,4-Tetra(2-furyl, 2-thienyl, and 2-selenienyl)butatrienes : Synthesis, Properties, and Molecular Structures
• 7,7-Dipyridyl-2,6-di-tert-butyl-p-quinone Methides : Synthesis, Complexation with Silver(I) Ion, and Oxidation to Their Pyridine N-Oxide
• Synthesis, Structure, and Properties of a Cyclopent[fg]acenaphthylene-1,2-bis(p-quinone methide)s Derivative. An Extended Pyracyloquinone
• Synthesis of Tetrakis(2-furyl)methane
• Stilbene-extended Trithienylmethanophanes : A Novel C_3-Symmetric Cage Molecule Capable of Accommodating an Organic Molecule As Well As Three Silver(I) Ions
• Bicyclo[10. 10. 10]dotriacontanes : the Largest Bicyclo[n. n. n]alkane Ever Known
• Synthesis, Structure, and Properties of a Dibenzo-ortho-terphenoquinone. The First o-Terphenoquinone Derivative
• Novel Monocation, Dication, and Dianion of a Cage Molecule, Trithienylmethanophane
• Adamantane-2,4-bis(p-quinone methide) and -2,6-bis(p-quinone methide) as New Models for Intramolecular Interactions between Spatially Separated Redox Systems
• Synthesis, Structure, and Properties of Hexaaryl[3]radialenes
• Dibenzoannulated 3, 5, 3, " 5"-Tetra(t-butyl)-p-terphenoquinone.A Reversible, Photochemical-Thermal Switching System Involving Restricted Conformational Change
• 8, 16, 24, 32-Tetramethoxy[2.2.2.2]metacyclophane-1, 9, 17, 25-tetrayne:A Novel Ionophore Having a Preorganized but Unexpectedly Flexible Cavity
• 2, 6-Di-tert-butyl-4-diarylmethylene-2, 5-cyclohexadiene-1-thiones.First Isolable Unannelated Thioquinone Methides
• Enhanced Nucleophilic Reactivity of a 4-Lithiophenoxide Ion and Its Application to the Synthesis of a Bis(4-hydroxyphenyl)methylenecyclopentadiene and Its Dianion, a Novel Extended Trimethylenemethane Dianion
• Alkali Metal Reduction of Oligo-6-[2-thienyl]pentafulvenes. Synthesis of Oligothienylemethines Attached with Cyclopentadienide Groups
• Validation of the Japanese version of the Roland-Morris Disability Questionnaire
• IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-I ANTIGENS (Immuno-Histochemistry and Cytochemistry)
• Identification of a Key Amino Acid of the Human 5-HT2B Serotonin Receptor Important for Sarpogrelate Binding
• Isolated Left Ventricular Noncompaction Was not a Very Rare Disorder in an Adult Population
• Habitual Walking Improves Distensibility of Central Artery in Patients with Essential Hypertension : Relation to Blood Pressure Reduction and Energy Metabolism
• Energy Spectrum of Ultra High Energy γ-Rays from Supernova
• Time Variation of Ultra High Energy γ-Ray from SN1987A
• Response Function Measurements of the Self-TOF Neutron Detector for Neutrons up to 800 MeV
• The Recovery of the Walking Ability of Patients at Early Stages after Total Hip Arthroplasty from the Perspective of the Displacement of the Center of Gravity
• Neuroprotection and Enhanced Recovery With Edaravone After Acute Spinal Cord Injury in Rats
• 5, 8, 17, 20- tetrakis(3, 5-di-t-butylphenyl)-6, 7, 18, 19-tetradehydrotetrathia[24]annulene-(4.0. 4.0)and Its Dianion : New Thiophene-Derived Paratropic and Diatropic Annulenes
• Expression Profile of Amylolytic Genes in Aspergillus nidulans
• β-Adrenoceptors: Three-Dimensional Structures and Binding Sites for Ligands
• An Off-Axis Jet Model for GRB 980425 and Low Energy Gamma-Ray Bursts(Poster)
• Erythropoietin Prevention Trial of Coronary Restenosis and Cardiac Remodeling After ST-Elevated Acute Myocardial Infarction (EPOC-AMI) : A Pilot, Randomized, Placebo-Controlled Study
• Pharmacological Tests in 100 Patients with Intractable Pain
• Raw Materials for Low-Activation Concrete Neutron Shields
• Correlation between Tritium and ^Eu Induced in Various Types of Concrete by Thermal Neutron Irradiation
• Design and Implementation of a Community-based Limb Salvage Program for ESRD Patients
• Inhibitory Effects of a Newly Synthesized 5-HT_2 Receptor Antagonist, AT-1015 (N-[2-[4-(5H-Dibenzo[a, d]cyclohepten-5-ylidene)piperidino]-ethyl]-1-formyl-4-piperidinecarboxamide Monohydrochloride Monohydrate), on Contraction and Relaxation of Pig Coronary
• Comparative Analyses of Fatty Acid Compositions in Rice Grain Glycerolipids among Three Cultivars with Different Chilling Susceptibilities
• 7,7,8,8 - Tetra(2 - thienyl) - p - quinodimethanes, New Electron - Donationg p - Quinodimethanes
• Light-Controlled Expression of a Foreign Gene Using the Chalcone Synthase Promoter in Tobacco BY-2 Cells
• Two-phase Search (TPS) Method: Nonbiased and High-speed Parameter Search for Dynamic Models of Biochemical Networks
• Pentaleno[1,2-c:4,5-c']dithiophene Derivatives : First Synthesis, Properties, and a Molecular Structure
• Triarylamines on [3]Radialene Scaffold : Novel [3]Radialene-based, Multistep, Wide-range Redox Systems with Remarkably Low Oxidation Potentials
• Clinical Utility of Evaluating Intracranial Artery Stenosis and Silent Brain Infarction to Predict the Presence of Subclinical Coronary Artery Disease in Ischemic Stroke Patients
• Diacenaphtho[1,2-b ; 1',2'-d]silole and -pyrrole
• Influence of light irradiation rates and irradiation modes on caffeine production and cell growth in suspension culture of Coffea arabica cells.
• Robust complementary hierarchical clustering for gene expression data analysis by β-divergence(BIOINFORMATICS)

もっと見る 閉じる

スポンサーリンク