Systemic Sclerosis after Interferon Alphacon-1 Therapy for Hepatitis C
スポンサーリンク
概要
- 論文の詳細を見る
A 66-year-old woman developed systemic sclerosis (SSc) after receiving interferon alphacon-1 (IFNαcon-1;consensus interferon) therapy for chronic hepatitis C. She suffered from Raynauds phenomenon about 1 year after a course of IFNαcon-1 therapy. The combination of proximal scleroderma, Raynauds phenomenon, and ANA positivity led to a diagnosis of systemic sclerosis (SSc). IFN has multiple effects on the immune system and is known to trigger the development of autoantibodies, as well as the onset or exacerbation of autoimmune disease. We suspect that the immunomodulatory effects of IFNαcon-1 triggered the clinical manifestations of SSc in this patient. To our knowledge this is only the third case of SSc after IFNα therapy, and it is the first case associated with IFNαcon-1 therapy.
- 社団法人 日本内科学会の論文
著者
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Okada Katsuyuki
Department Of Dermatology Gunma University School Of Medicine
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Mori Masatomo
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Gunma University
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Ban Satoshi
Department Of Clinical Laboratories Gunma University School Of Medicine
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Yoshida Katsue
Department Of Pathology And Clinical Laboratories Kiryu Welfare General Hospital
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Tahara Hiroki
Department Of Medicine And Molecular Science Gunma University School Of Medicine
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Maruta Sakae
Department of Internal Medicine, Kiryu Kosei General Hospital
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Hirokawa Tomoyuki
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Takagi Hitoshi
Department Of 1st Internal Medicine Gunma University School Of Medicine
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Kojima Akira
Department Of Chemical And Materials Science Gunma National College Of Technology
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Naganuma Atsushi
Department Of Medicine And Molecular Science Gunma University Graduate School Of Medicine
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Kojima Akira
Department of Internal Medicine, Kiryu Kosei General Hospital, Kiryu
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Ban Satoshi
Department of Pathology, Kiryu Kosei General Hospital, Kiryu
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Oyama Tatsuya
Department of Internal Medicine, Kiryu Kosei General Hospital
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