Pradimicin Resistance of Yeast Is Caused by a Mutation of the Putative N-Glycosylation Sites of Osmosensor Protein Sln1
スポンサーリンク
概要
- 論文の詳細を見る
Pradimicin, a mannose-binding antifungal antibiotic, induces apoptosis-like cell death in Saccharomyces cerevisiae. Previously we found that the substitution of the 74th amino acid from glycine to cysteine in Ypd1 yields a mutant resistant to pradimicin. In this study, the involvement of a membrane-spanning osomosensor, Sln1, which is located upstream of Ypd1, was investigated. A mutant, sln1 ΔNG, that lacks the putative N-glycosylation sites in the extracellular domain became resistant to pradimicin. On the other hand, the null mutants of Ssk1, Pbs2, and Hog1, which are located downstream of the Sln1 cascade, were sensitive to pradimicin as well as the wild-type strain. In conclusion, pradimicin exerts its fungicidal action with the involvement of Sln1, but the downstream branch, Ssk1 and the HOG pathway, is not involved.
- 社団法人 日本農芸化学会の論文
- 2005-01-23
著者
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Fujita T
Suntory Institute For Bioorganic Research
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Oki Toshikazu
Biotechnology Research Center Toyama Prefectural University
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Furuki T
Natural History Museum & Institute
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Nomura Nobuhiko
Biotechnology Research Center Toyama Prefectural University
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IGARASHI Yasuhiro
Biotechnology Research Center, Toyama Prefectural University
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FURUMAI Tamotsu
Biotechnology Research Center, Toyama Prefectural University
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HIRAMOTO Fumitaka
Biotechnology Research Center, Toyama Prefectural University
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Furumai Tamotsu
Biotechnology Research Center Toyama Prefectural University
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Tomoyuki Fujita
Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak
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Fujita Tomoyuki
Dep. Of Sciences Of Functional Foods Graduate School Of Agriculture Shinshu Univ.
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Igarashi Yasuhiro
Biotechnology Research Center Toyama Pref. Univ.
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Furumai T
Biotechnology Research Center Toyama Prefectural University
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Hiramoto Fumitaka
Biotechnology Research Center Toyama Prefectural University
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Oki Toshikazu
Biocatalysis And Biochemistry Toyama Prefectural University Biotechnology Research Center
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Igarashi Y
Biotechnology Research Center Toyama Prefectural University
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