Pradimicin, a Mannose-binding Antibiotic, Induced Carbohydrate-mediated Apoptosis in U937 Cells
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概要
- 論文の詳細を見る
Pradimicin (PRM), a mannose-binding antifungal antibiotic, recognizes a D-mannoside in the presence of calcium. We demonstrated that BMY-28864, a semi-synthetic analog of PRM, induced apoptosis in U937 cells which had been incubated with 1-deoxymannojirimycin (DMJ). Characteristic morphological changes such as formation of apoptotic bodies and DNA fragmentation were observed in apoptotic cells.
- 社団法人日本農芸化学会の論文
- 1997-08-23
著者
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Yamazaki Y
Cancer Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Yamada Y
Taiho Pharmaceutical Co. Ltd. Saitama
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Tomoyuki Fujita
Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak
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OKI Toshikazu
Toyama Prefectural University, Biotechnology Research Center
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YAMAZAKI Yoko
Toyama Prefectural University, Biotechnology Research Center
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FURUMAI Tamotsu
Toyama Prefectural University, Biotechnology Research Center
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IGARASHI Yasuhiro
Toyama Prefectural University, Biotechnology Research Center
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Oki Toshikazu
Biocatalysis And Biochemistry Toyama Prefectural University Biotechnology Research Center
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