Production of antioomycete compounds active against the phytopathogens Phytophthora sojae and Aphanomyces cochlioides by clavicipitoid entomopathogenic fungi(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

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概要

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• A total of 412 strains belonging to 14 genera of clavicipitoid entomopathogenic fungi (EPF) were screened for activities against two economically important plant pathogenic oomycetes, Phytophthora sojae and Aphanomyces cochlioides. To identify the antioomycete compounds produced by EPF, the extracts of 13 highly active EPF strains were characterized in detail by high performance liquid chromatography with diode array detection and high-resolution mass spectrometric detection and antioomycete assay. The antioomycete activity of several Metarhizium extracts was associated with previously isolated aurovertins, fungerin, N-(methyl-3-oxodec-6-enoyl)-2-pyrroline, and N-(methyl-3-oxodecanoyl)-2-pyrroline. The depsipeptide beauvericin was confirmed to be one of the active principles of three strains of Isaria tenuipes, which strongly inhibited mycelial growth of both P. sojae and A. cochlioides. Two known bioactive metabolites, paecilosetin and aranorosinol A, together with a novel and potent antioomycete compound, farinomalein, were isolated from the extracts of Isaria farinosa and all compounds were confirmed to have antioomycete activity. Identification of 8 antioomycete compounds from 13 clavicipitioid EPF demonstrated a new potential use of EPF as a source of compounds for the control of soil-borne plant pathogenic oomycetes.

• 公益社団法人日本生物工学会の論文

著者

• Ihara Fumio

  National Inst. Of Fruit Tree Sci.

• Igarashi Yasuhiro

  Biotechnology Research Center Toyama Pref. Univ.

• Kitani Shigeru

  International Center For Biotechnology Osaka University

• Kinoshita Hiroshi

  International Center For Biotechnology Osaka University

• Nihira Takuya

  International Center For Biotechnology Osaka Univ.

• Putri Sastia

  International Center For Biotechnology Osaka University

• Nihira Takuya

  International Center for Biotechnology, Osaka University:MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University

• Ishido Kei-ichi

  International Center for Biotechnology, Osaka University

• Sakihama Yasuko

  Research Faculty of Agriculture, Hokkaido University

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