A New Differentiation Inducer of Friend Leukemia Cells, Trichostatic Acid
スポンサーリンク
概要
- 論文の詳細を見る
FL-657B, which induced differentiation of Friend leukemia cells, was isolated from the culture fluid of Streptomyces sioyaensis and identified with trichostatic acid, a hydrolysis product of trichostatiir A and C. FL-657B induced hemoglobin biosynthesis of both dimethyl sulfoxidesensitive and -resistant Friend leukemia cells. FL-657B caused approximately 90% of the cells to be benzidine positive and reduced the growth to approximately 30-70% of the control at 2.42μg/ml. Hemoglobin newly biosynthesized by the induction of FL-657B showed a UV absorption pattern similar to that from the normal mouse.
- 社団法人 日本農芸化学会の論文
著者
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Hirayama Kazuo
Central Research Laboratories Ajinomoto Co. Inc.
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Morioka Hajimu
Central Research Laboratories Ajinomoto Co. Jnc.
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Shibai Hiroshiro
Central Research Laboratories Ajinomoto Co. Inc.
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TAKEZAWA Misako
Central Research Laboratories, Ajinomoto Co., Inc.
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Suzuki Eiichiro
Central Research Laboratories Ajinomoto Co.
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KOMODA Yasuo
Research Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
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ISHIHARA Masaru
Central Research Laboratories of Ajinomoto Co. Inc.
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ISHIHARA Masaru
Central Research Laboratories, Ajinomoto Co., Ltd.
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HIRAYAMA Kazuo
Central Research Laboratories, Ajinomoto Co., Ltd.
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TAKEZAWA Misako
Central Research Laboratories, Ajinomoto Co., Ltd.
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MORIOKA Hajimu
Central Research Laboratories, Ajinomoto Co., Ltd.
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SUZUKI Eiichiro
Central Research Laboratories, Ajinomoto Co., Ltd.
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