Inhibition by Hadacidin, Duazomycin A, and Other Amino Acid Derivatives of de novo Starch Synthesis

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Two amino acid derivative antibiotics, hadacidin and duazomycin A, were isolated as inhibitors of de novo starch synthesis in excised leaf segments from culture filtrates of Penicillium No. 467 and Streptomyces No. 317, respectively. In addition, azaserine, 6-diazo-5-oxo-L-norleucine (DON), and trifluoro-DL-methionine were found to be potent inhibitors among about 70 kinds of commercial amino acid derivatives. These amino acid derivatives inhibited de novo starch synthesis at concentrations ranging from 1 to 10ppm but did not inhibit photosynthetic oxygen evolution at a concentration of 100ppm. The inhibition caused by these diazo compounds was reversed by a supplement of L-glutamine. With hadacidin and trifluoro-DL-methionine, however, the reversal was not observed upon the addition of L-aspartic acid or L-methionine, respectively. Among these active compounds, hadacidin was herbicidal against lettuce and barnyard millet by foliar treatment at a concentration of more than 1000ppm.
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