Production and Isolation of Cosmomycins A, B, C and D: New Differentiation Inducers of Friend Cell F5-5

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概要

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• Cosmomycins A, B, C and D, new differentiation inducers of Friend cell F5-5, accumulated in the mycelium and culture fluid of a new strain, Streptomyces cosmosus nov. sp. Cosmomycin A and cosmomycin B contain a rhodinosyl-rhodinosyl-rhodosaminyl and rhodinosyl-2-deoxy-L-fucosylrhodosaminyl group at C-10 of γ-rhodomycinone, respectively. Cosmomycins C and D respectively possess the same sugar chains as Cosmomycins A and B at C-10 and the common rhodinosyl-2-deoxy-L-fucosyl-rhodosaminyl group at C-7 of β-rhodomycinone. Cosmomycin D is a new anthracycline compound and cosmomycin A is a new anthracycline compound of microbial origin, but Cosmomycins B and C seem to be identical to γ-rhodomycin Y and β-rhodomycin S-2, respectively. Approximately 20.0%, 15.4%, 16.4% and 14.2% of the F5-5 cells were induced to respectively biosynthesize hemoglobin by 1.25 μg/ml of cosmomycin A, 1.25 μg/ml of cosmomycin B, 7.81ng/ml of cosmomycin C and 15.6ng/ml of cosmomycin D. Other anthracyclines such as aclacinomycin A1, adriamycin and daunomycin had no effect on differentiation.

• 社団法人 日本農芸化学会の論文

著者

• ANDO Toshihiko

  Central Research Laboratories, Ajinomoto Co., Inc.

• HIRAYAMA Kazuo

  Central Research Laboratories, Ajinomoto Co., Inc.

• HORINO Issei

  Central Research Laboratories, Ajinomoto Co., Inc.

• ETOH Yuzuru

  Central Research Laboratories, Ajinomoto Co., Inc.

• Hirayama Kazuo

  Central Research Laboratories Ajinomoto Co. Inc.

• Morioka Hajimu

  Central Research Laboratories Ajinomoto Co. Jnc.

• Shibai Hiroshiro

  Central Research Laboratories Ajinomoto Co. Inc.

• Kano Hideo

  Central Research Laboratories Of Ajinomoto Co. Inc.

• TAKEZAWA Misako

  Central Research Laboratories, Ajinomoto Co., Inc.

• KANO Hideo

  Central Research Laboratories, Ajinomoto Co., Inc.

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