Differentiation Inducing Activity of Anthracycline Compounds in Friend Leukemia Cells(Organic Chemistry)
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概要
- 論文の詳細を見る
Several kinds of anthracyclines having γ-rhodomycinone as the aglycone were isolated from Streptomyces cosmosus TMF 518, and their derivatives were prepared by chemical modification. We tested their differentiation inducing activity in Friend leukemia cells and clarified their structure activity relationship as follows: 1) The aglycone, γ-rhodomycinone, had no differentiation inducing activity but was cytotoxic; 2) the compounds with two sugar chains at both C7 and C10 had more potent differentiation inducing activity than those with only a sugar chain at C-10; 3) cosmomycin C was the most favorable candidate for an anticancer agent of all anthracyclines tested, because the value of ED_<50> (cytotoxicity)/ED_<50> (differentiation) was as high as 3000; and 4) the increase in differentiation inducing activity and cytotoxicity was not always in parallel.
- 社団法人日本農芸化学会の論文
- 1986-07-23
著者
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ANDO Toshihiko
Central Research Laboratories, Ajinomoto Co., Inc.
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MORIOKA Hajimu
Central Research Laboratories, Ajinomoto Co., Inc.
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SHIBAI Hiroshiro
Central Research Laboratories, Ajinomoto Co., Inc.
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MURAI Asao
Central Research Laboratories, Ajinomoto Co., Inc.
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Murai A
Ajinomoto Co. Inc. Kawasaki Jpn
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Ando T
Ajinomoto Co. Inc. Kawasaki Jpn
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Morioka H
Ajinomoto Co. Inc. Kawasaki Jpn
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Morioka Hajimu
Central Research Laboratories Ajinomoto Co. Jnc.
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Tsuji T
Ajinomoto Co. Inc. Kawasaki Jpn
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Tsuji Tomoko
Central Research Laboratories Ajinomoto Co. Inc.
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Shibai H
Central Research Laboratories Of Ajinomoto Co. Inc.
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Shibai Hiroshiro
Central Research Laboratories Ajinomoto Co. Inc.
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TAKEZAWA Misako
Central Research Laboratories, Ajinomoto Co., Inc.
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TAKEZAWA Misako
Ajinomoto Central Research Laboratories
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Murai Asao
Central Research Laboratories, Ajinomoto Co. Inc.
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Murai Asao
Central Research Laboratories, Ajinomoto Co, Inc.
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