Analysis of antibody response by temperature-sensitive measles vaccine strain in the cotton rat model
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概要
- 論文の詳細を見る
Measles virus (MeV) vaccine strain, AIK-C, is temperature sensitive (ts), which is thought to be associated with attenuation of virus pathogenicity. In this study, replication and antibody response were examined in cotton rats using viruses carrying different forms of the P gene, which is responsible for the ts phenotype of strain AIK-C and its parental Edmonston strain. When cotton rats were inoculated intranasally, ts viruses neither replicated in lungs, nor reproducibly generate an antibody response. When inoculated intramusculary (IM), however, ts strains raised an antibody titer in all animals. This response was not observed when ultraviolet-inactivated virus was used. Ts virus, inoculated IM, was recovered from cotton rat drainage lymph nodes. These results suggest that ts virus, inoculated IM, could replicate in the cotton rat, presumably at the superficial lymph node, and induce an antibody response. Therefore, cotton rats can serve as a small-animal model for investigating immune responses to safer ts vaccine, as well as recombinant vaccine using AIK-C as a vector for protection against other infectious agents.
著者
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篠原 明男
宮崎大学フロンティア科学実験総合センター実験支援部門生物資源分野
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KOSHIMOTO Chihiro
Frontier Science Research Center, University of Miyazaki
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Morita Tetsuo
Faculty Of Agriculture Miyazaki University
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森田 哲夫
宮崎大・農・食料生産
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森田 哲夫
宮崎大学農学部生態生理学教室
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Morita Tetsuo
Department Of Animal Science Faculty Of Agriculture Miyazaki University
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森田 哲夫
京都大学農学部
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Koshimoto Chihiro
Department Of Bio-resources Division Of Biotechnology Frontier Science Research Center University Of
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Morita Tetsuo
Laboratory Of Physiological Ecology Faculty Of Agriculture University Of Miyazaki
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Koshimoto Chihiro
Frontier Science Research Center University Of Miyazaki
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Morita Tetsuo
Animal Nutrition Laboratory Faculty Of Agriculture University Of Miyazaki
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