Prazosin Stimulates the Release of Hepatic Triacylglycerole Lipase Caused from Primary-culture Rat Hepatocytes
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概要
- 論文の詳細を見る
Prazosin is an alpha 1 adrenoceptor antagonist, and it is used as an antihypertensive agent. The effects of prazosin on the activity of hepatic triacylglycerole lipase (HTGL) are not fully understood. In this study, we demonstrated that prazosin stimulates the release of HTGL activity from primary cultures of rat hepatocytes in a time- and dose-dependent manner. U-73122, a phopholipase C (PLC) inhibitor, suppresses prazosins stimulation of the release of HTGL activity. Moreover, prazosin stimulated the increase of PLC activity in the hepatocytes in a time- and dose-dependent manner. In addition, the prazosin-stimulated release of HTGL activity was reduced by Quin2/AM (an intracellular Ca2+-chelator), W-7 (a Calmodulin inhibitor), and KN-93 [an inhibitor of Ca2+/Calmodulin dependent protein kinase (CaMK)-II]. These results suggest that the prazosin-stimulated release of HTGL activity is partly due to the activation of CaMK-II that is associated with the elevation of PLC activity in the hepatocytes.
- 公益社団法人 日本薬学会の論文
著者
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Morita Tetsuo
Dep. Of Biochemistry Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
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Morita Tetsuo
Department Of Animal Science Faculty Of Agriculture Miyazaki University
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Nakamura Tetsuya
Department Of Infectious Disease And Applied Immunology The Institute Of Medical Science The Univers
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Kerakawati Rie
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Kerakawati Rie
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Fukuyama University
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Nakamura Tetsuya
Department Of Gastroenterology And Hepatology Graduate School Tokyo Medical And Dental University
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Nakamura Tetsuya
Department Of Endoscopy Dokkyo University School Of Medicine
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森田 哲生
福山大学 薬学部 生化学
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Morita Tetsuo
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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