Endothelin-1 Stimulates Secretion of Lipoprotein Lipase from Ehrlich Ascites Tumor Cells
スポンサーリンク
概要
- 論文の詳細を見る
Since the role of endothelin (ET)-1 in lipoprotein metabolism in tumor cells is unclear, we investigated the effect of ET-1 on the secretion of lipoprotein lipase (LPL) from mouse Ehrlich ascites tumor cells. ET-1 increased the secretion of LPL from these cells in a time-dependent manner. Two antagonists of ET-receptor type A (ET-A), namely, BQ123 and FR139317, inhibited the stimulatory effect of ET-1 on the secretion of LPL. However, an antagonist of ET-receptor type B (ET-B), BQ788, did not have any effect. Neomycin, a phospholipase C (PLC) inhibitor, and H-7, a protein kinase C (PKC) inhibitor, also suppressed the ET-1-stimulated secretion of LPL. ET-1 also increased PKC activity in tumor cells in a dose-dependent manner. These results imply that ET-1 stimulates secretion of LPL from tumor cells by stimulating the PLC-PKC signaling pathway through the ET-A receptor rather than the ET-B receptor.
著者
-
Morita Tetsuo
Dep. Of Biochemistry Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
-
Morita Tetsuo
Department Of Animal Science Faculty Of Agriculture Miyazaki University
-
Kerakawati Rie
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Fukuyama University
-
森田 哲生
福山大学 薬学部 生化学
-
Morita Tetsuo
Department of Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
関連論文
- Endothelin-1 Stimulates Secretion of Lipoprotein Lipase from Ehrlich Ascites Tumor Cells
- 山林放飼養鶏における野生鳥獣害
- インドネシア薬用植物第XXIV報 : Scurrula fusca(ヤドリギ科)葉から単離したPerseitol・K^+イオン錯体の立体化学構造(発表論文抄録(2003))
- 乾燥焼酎粕の混合割合の違いが肥育豚の発育成績および肉質に及ぼす影響について
- ワイン粕給与が肥育豚の発育と枝肉・肉質特性に及ぼす影響
- エコフィードを活用した低コスト高品質豚肉生産技術に関する研究
- 焼酎粕乾燥脱水ケーキの給与が搾乳牛の乳量,乳質,風味等に及ぼす影響(フィールド試験)
- 飼育下のニホンヤマネGlirulus japonicusで見られる脱毛現象
- 琉球在来島豚の交雑種における肉質特性
- 宮崎県でのヤマネ発見に関する報告--1998,2004年の事例
- 飼料中油脂原料の違いが鶏肉の脂質過酸化に及ぼす影響
- Pipecolic acid in rumen fluid and plasma in ruminant animals
- Orthovanadate Stimulates cAMP Phosphodiesterase 3 Activity in Isolated Rat Hepatocytes through Mitogen-Activated Protein Kinase Activation Dependent on cAMP-Dependent Protein Kinase(Biochemistry/Molecular Biology)
- EFFECTS OF GONADAL HORMONES ON THE DAILY TORPOR IN MALE AND FEMALE KOREAN FIELD MICE, APODEMUS PENINSULAE
- EFFECTS OF PHOTOPERIOD, TEMPERATURE AND TESTOSTERONE ON DAILY TORPOR IN THE KOREAN FIELD MOUSE, APODEMUS PENINSULAE
- グラントシマウマ Equus burchelli bohmi の子馬における食糞
- Body temperature profiles of the Korean field mouse Apodemus peninsulae during winter aggregation
- 制癌剤含有リポソームの腫瘍細胞取り込みに対するpolyethyleneglycol修飾化の影響
- オルトバナデートはPKAに依存したMAPキナーゼの活性化を介して、ラット肝細胞中のcAMPホスホジエステラーゼ3を活性化させる(発表論文抄録(2005))
- 結腸癌26移植マウスにおけるリポ蛋白質代謝の変動に対するメドロキシプロゲステロンの効果
- ラット肝細胞からのヘパリンによる肝性リパーゼの遊離におけるロイコトリエン産生の関与(発表論文抄録(2006))
- ヘパリンによるラット肝培養細胞中のロイコトリエンB_4の急速な増加(発表論文抄録(2005))
- ヘパリンによるラット肝細胞からの肝性リパーゼ活性放出機構に、Ca^/カルモジュリン依存性プロテインキナーゼIIが含まれる。(発表論文抄録(2005))
- 初代培養ラット肝細胞系における肝性リパーゼ放出機構の解析に関する研究
- Effects of Nitrogen Dioxide Exposure on the Level of Ascorbc Acid in theUrine and Tissues of Rats
- Indonesian Medicinal Plants. XXIV. Stereochemical Structure of Perseitol・K^+ Complex Isolated from the Leaves of Scurrula fusca(Loranthaceae)
- Production of aromatic amino acids and related compounds from p-hydroxyphenylacetic acid by rumen microorganisms in vitro
- In vitro metabolism of tyrosine by rumen bacteria, protozoa and their mixture
- A quantitative study on arginine synthesis from argininosuccinic acid and citrulline by crude enzymes of cattle kidney
- Synthesis of citrulline from ornithine by the small intestinal mucosa of cattle
- 初代培養ラット肝細胞系におけるデキストラン硫酸による肝性リパーゼの分泌促進
- オカダ酸はマウス脂肪組織中のレプチン含量を減少させる(発表論文抄録(2004))
- 乳癌 : 特に進行・再発乳癌の黄体ホルモン療法について(発表論文抄録(2002))
- 抗レプチン受容体抗体のマウス摘出脂肪組織に対するレプチン類似脂肪分解促進作用(発表論文抄録(2002))
- バナデートによるマウス脂肪組織からのレプチン分泌抑制(発表論文抄録(2002))
- バナジル-BSA錯体によるcAMPおよびイノシトール1,4,5-三リン酸含量増加を介するリポ蛋白質リパーゼ活性放出(発表論文抄録(2000))
- バナデートのリポ蛋白質リパーゼ活性放出促進機構へのアデノシンの関与
- Orthovanadate Decreases Leptin Secretion from Isolated Mouse Fat Pads
- A Vanadyl Sulfate-Bovine Serum Albumin Complex Stimulates the Release of Lipoprotein Lipase Activity from Isolated Rat Fat Pads through an Increase in the Cellular Content of cAMP and myo-Inositol 1,4,5-Trisphosphate
- Enhancement of the Vanadate-Stimulated Release of Lipoprotein Lipase Activity be Astilbin from the Leaves of Engelhardtia Chrysolepis
- Involvement of Leukotriene Production in Release of Hepatic Lipase Activity Produced by Heparin from Rat Hepatocytes
- Rapid Increase in the Leukotriene B_4 Concentration of Cultured Rat Hepatocytes by Heparin
- Involvement of Ca^/Calmodulin-Dependent Protein Kinase II in Heparin-Stimulated Release of Hepatic Lipase Activity from Rat Hepatocytes(Biochemistry/Molecular Biology)
- Microflora in the Rearing Water of Japanese Flounder(Paralichthys olivaceus) at the Larval Stage
- Prazosin Stimulates the Release of Hepatic Triacylglycerole Lipase Caused from Primary-culture Rat Hepatocytes
- Release of Lipoprotein Lipase Induced by L-Arginine in Mouse Mammary Tumor FM3A Cells
- Effect of the Temperature-Humidity Index on Body Temperature and Conception Rate of Lactating Dairy Cows in Southwestern Japan
- 乾燥焼酎粕ケーキ給与期間の違いが肥育豚の発育, 枝肉, 肉質に及ぼす影響
- 乾燥焼酎粕ケーキの添加レベルが肥育豚の生産性, 枝肉形質, 肉質に及ぼす影響
- Analysis of antibody response by temperature-sensitive measles vaccine strain in the cotton rat model
- 鹿児島県本土部における国内外来種オキナワキノボリトカゲJapalura polygonata polygonata(Hallowell, 1861)(爬虫綱，アガマ科)の生息状況
- Vitamins A and E in Carcass Fat from Japanese Black and F1 Cross Cattle
- 転移性乳癌患者における、エイコサペンタエン酸(EPA)強化濃厚流動食投与のおよぼす効果
- Sulfurization of sintered reduced iron with hydrogen sulfide and its overall rate description by volume reaction model.