Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)
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概要
- 論文の詳細を見る
We evaluated endothelial function of thoracic aortas and pulmonary arteriesin a population of European wood mice (Apodemus sylvaticus), whichexhibits hypercholesteromia. According to the plasma cholesterol level,mice were divided into two groups: hypercholesterolemic (AHL, totalplasma cholesterol 200-300 mg/dl) and normocholesterolemic (ANL, totalplasma cholesterol <200 mg/dl). Acetylcholine (ACh) causedendothelium-dependent relaxation of precontracted aortas and pulmonaryarteries. Relaxation of the pulmonary artery is completely dependent onnitric oxide. This relaxation was inhibited in AHL pulmonary arteries.On the other hand, part of the ACh-induced relaxation of the thoracic aortawas resistant to Nω-nitro-L-arginine (L-NNA). L-NNA-sensitive and-resistant relaxation to ACh were also inhibited in AHL aortas. Inhibitionof endothelium-dependent relaxation of the aortas was correlated with totalplasma cholesterol level. Endothelium-independent relaxation to sodiumnitroprusside (SNP) was similar in AHL and ANL pulmonary arteries, butin the thoracic aorta of AHL mice, the sensitivity to SNP was slightlydecreased, without a change in maximal response to SNP. Nomorphological change was observed in the aortas and the pulmonaryarteries from AHL and ANL mice. Thus, AHL mice are valuable as a newexperimental model to study the relation of hyperlipidemia to vasculardisease since the endothelial function is impaired in these mildhyperlipidemic animals.
- Elsevierの論文
- 2007-08-00
著者
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篠原 明男
宮崎大学フロンティア科学実験総合センター実験支援部門生物資源分野
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KOSHIMOTO Chihiro
Frontier Science Research Center, University of Miyazaki
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TSUCHIYA Kimiyuki
Department Zootechnical Science, Tokyo University of Agriculture
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Tsuchiya Kimiyuki
Experimental Animal Center, Miyazaki Medical College
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Tsuchiya Kimiyuki
Laboratory Of Wild Animals Department Of Animal Sciences Faculty Of Agriculture Tokyo University Of
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Koshimoto Chihiro
Department Of Bio-resources Division Of Biotechnology Frontier Science Research Center University Of
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Koshimoto Chihiro
Frontier Science Research Center University Of Miyazaki
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Tsuchiya Kimiyuki
Laboratory of Wild Animals, Department of Animal Sciences, Tokyo University of Agriculture
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