難消化性デキストリン負荷による糖尿病リスクの軽減効果について

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Objective: Early identification of pre-diabetes and subsequent dietary counseling and exercise guidance are thought to be important in the prevention of the onset of diabetes. We initially conducted an intervention study to determine the effects of dietary fiber on the reduction of diabetes risk. However, it was difficult for subjects to maintain an adequate daily intake of fiber from diet alone. We therefore introduced a supplement that could be easily taken and would boost the dietary fiber intake of subjects. The purpose of the current study was to determine the reduction in diabetes risk of dietary loading with digestion resistant dextrin. Design and methods: Forty-six volunteers, who were pre-obese, were divided into two groups and studied in a crossover design intervention study consisting of a 3-month study period and one-month interval between treatment periods. The supplement group was given resistant dextrin (dietary fiber content, 13.8 g/day) for 3 months while the control group did not receive any supplement. The biomarkers leptin, adiponectin, soluble insulin receptor and insulin in urine and blood were measured by an ultra-sensitive enzyme immunoassay (ICT-EIA method). Results: 1.5-Anhydro-D-glucitol (1.5-AG) levels, an index of postprandial hyperglycemia, were significantly improved in the supplement group compared to controls. Although significant improvements in HbA1c levels were observed in both the supplement and control groups after the study period, there were no significant differences between these two treatment groups. We observed no significant changes in the levels of the biomarkers at the end of the study period. Conclusion: Supplementation with digestion-resistant dextrin for 3 months resulted in an improvement in postprandial hyperglycemia but did not result in improvements in HbA1c, fasting blood glucose levels and biomarkers.
2013-03-00

難消化性デキストリン負荷による糖尿病リスクの軽減効果について

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