高タンパク質食におけるビタミンB_6の抗体産生に対する影響

概要

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When mice were fed on extreme vitamin B_6 deficient diets, the ovalbumin-dependent antibody productions (IgE, IgG1)were significantly suppressed. In this case, the alanine aminotransferase activity and the aspartate aminotransferase activity in the liver were also significantly decreased. In the case of pyridoxine excess (6 mg% = about ten times of standard amount) with high protein (70% casein) diet, the ovalbumin-dependent antibody productions (IgE, IgG1) were also considerably sup pressed. These responses were much weaker in a normal casein (20% casein) diet. The administra tion of high doses of pyridoxine (6 mg%) resulted in the suppression of hepatic cathepsin B activity. Therefore, ovalbumin-dependent antibody productions (IgE, IgG1) were suppressed by the pyridox ine excess diet, especially in the case of a high protein diet.
日本ビタミン学会の論文
2000-03-25