附子とMesaconitineの亜急性および亜慢性毒性

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Raw aconite and processed aconite extracts and a known toxic principle therein, mesaconitine, were tested for their subacute (2 weeks) and subchronic (12 weeks) p.o . toxicity in mice and rats. Their effect on behavior, general appearance, mortality, body weight, or organ weight and hematological, blood biochemical, and gross and microscopic pathological changes caused by them were also recorded. In subacute toxicity test, all the rats treated with raw aconite or mesaconitine at doses of 1.1 g/kg/day and 1.3 mg/kg/day (ca. 1/2 of LD_<50>), respectively, died in 3-6 days. In DDI-strain mice treated with raw aconite at a dose of 800 mg/kg/day (ca. 1/2 of LD_<50>), decrease in the number of erythrocytes and in the serum levels of total protein and of albumin were observed. In subchronic toxicity test, decrease in body weight was observed in rats treated with mesaconitine at a dose of 0.4 mg/kg/day. Glutamic-oxaloacetic transaminase and lactic dehydrogenase levels were also found to decreacv in the animals treated with raw or processed aconite at doses of 0.08-0.32 g/kg/day and 5-20 g/kg/day, respectively. Alkaline phosphatase level was elevated in mice and low ered in rats, when they were treated with raw aconite or mesaconitine. Pathological examination showed slight focal cell infiltration in liver of some mice treated with raw aconite or mesaconitine at doses of 0.08-0.32 g/kg/day and 0.1-0.4 mg/kg/day, respectively. No significant pathological change was observed in mice treated with processed aconite at a dose of 1 g/kg/day.
日本生薬学会の論文
1983-03-20

附子とMesaconitineの亜急性および亜慢性毒性

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