杜仲葉エキスの血圧降下に関する研究(第2報)

概要

論文の詳細を見る
In order to clarify the mechanism of the antihypertensive effect of Eucommia leaf (Eucommia ulmoides Oliver) extract (ELE), ELE was partitioned into two fractions, water eluted fraction (H_2O ext.) and methanol eluted fraction (MeOH ext.)(Eueommia leaf glycoside), by using a Diaion HP-20 column. The antihypertensive effects of ELE and two fractions were investigated by their intravenous (i.v.) administration to SHR. Transient antihypertensive effects were shown in ELE and MeOH ext. and their effects were respectively attenuated by i.v. injection of atropine, suggesting that the antihypertensive effects of both ELE and MeOH ext. might be mediated via the muscarinic acetylcholine receptors. On the other hand, H_2O ext. showed the sustained antihypertensive effect which was not attenuated by i.v. injection of atropine. This result suggested that two types of components which have different mechanisms of antihypertensive effect are contained in ELE.
日本生薬学会の論文
2005-06-20