T0302-3-5 医療用マイクロニードルアレイの刺入における力学的因子に着目した設計・評価手法([T0302-3]高信頼マイクロ・ナノデバイスのための設計・計測技術(3):微小構造部材の加工・評価)

概要

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Aiming at the robust design of medical microneedle array, design and evaluation system that consists of insertion test using cultured human skin and numerical simulation has been developed. Experimental results implied the importance of tension of skin, curvature of skin surface and pressing direction during insertion. To consider these factors that have uncertainty in the robust design from mechanical standpoint, the numerical simulation adopted 2-dimensional linear elastic model, although the insertion phenomenon is highly nonlinear. Among a number of design parameters of microneedle array, the effects of needle pitch, tip angle and number of needles on the deformation and local strain of skin are analyzed for some cases of curved skin surface.
2010-09-04