J0201-2-1 ワクチン投与用剣山形マイクロ微小針の製造に関する検討(ドラッグデリバリーシステムとその周辺技術の基礎と展開(2))

概要

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A new fabrication method of a painless micro needle array for high reliable vaccine delivery system through a epidermis is proposed. This method has been developed to realize the inexpensive and mass production of the needle array. For safety against the break of the needle, the needle is made with biogradable polymer (PLA). The proposed method has the following processes, (1) Si tool in a shape of micro needle array is heated, (2) tops of the needles over the Si tool are touched onto the surface of the polymer plate to melt the contacting areas, and (3) the Si tool is detached from the plate to form the needles by elongating the melted polymer. In order to make the uniform needles over the plate, temperature, touching time, and withdrawing speed of the Si tool and tolerance of the polymer plate are examined. By the optimized working conditions, keen corn-type needles having the height of about 500μm can be formed enable to penetrate into the epidermis.
2009-09-12