ベーチェット病患者好中球に対する補体C5aの影響

概要

論文の詳細を見る
Behcet's disease is a multisystem disorder that presents with recurrent oral and genital ulcerations as well as ocular involvement. The etiology and pathogenesis of the disease remain obscure, however, neutrophil dysfunction is thought to be involved. Complement (C5a) is a potent neutrophils chemoattractant and is known to mediate many types of inflammatory responses. To elucidate the relationship between neutrophils and C5a in Behcet's disease, the peripheral neutrophils of 31 patients with Behcet's disease and of 16 sex-age-matched normal controls were studied. Expression of C5a receptor mRNA was detected in Behcet' s disease but not in the normal controls (p=0.045). Chemotaxis (p=0.011) and superoxide release (p=0.001) by Behcet's neutrophils was significantly higher than by normal neutrophils, and the intracellular calcium mobilization of Behcet' s neutrophils was more active than that of normal neutrophils (p=0.004). Based on these results, we conclude that Beh cet's disease is associated with priming of peripheral neutrophils in vivo, suggesting that C5a may play a role in the etiology and pathogenesis of Behcet's disease.
東京女子医科大学の論文
2000-03-25