Effects of Amino Acids on Malarial Heme Crystallization

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概要

• 論文の詳細を見る

• To gain insight into the mechanism of malarial hemozoin formation and to explore various biological groups for screening novel antimalarial drugs, we examined the effects of amino acids on the formation of β-hematin (BH), which is a synthetic heme crystal structurally identical to hemozoin, in vitro. Our results showed that BH formation was significantly inhibited by basic amino acids (arginine, lysine, and histidine), probably due to the abilities of these amino acids to complex with heme. The results suggest an involvement in the improvement of the blood-schizonticidal activity of 8-quinolinamine when conjugated with basic amino acids. In addition, cysteine also inhibited BH formation, possibly due to its ability to reduce heme iron or decompose heme in acidic conditions. In contrast, BH formation was enhanced by amino acids with high hydrophobicity values (leucine, isoleucine, valine, methionine, and phenylalanine), with the exception of tryptophan at high temperature but was not affected in Tween-induced BH formation under normal physiological conditions. The present results can lead to further research on the development of new antimalarials by conjugating these amino acids, especially basic amino acids, with other substances, or by forming complex or small peptides that could have special effects on BH formation.

• 公益社団法人日本薬学会の論文
• 2008-08-01

著者

• HIRAYAMA Kenji

  Department of Physics, Chiba University

• Oida Tatsuo

  Department of Chemistry and Materials Technology, Kyoto Institute of Technology

• Hirayama Kenji

  Department Of Immunogenetics Institute Of Tropical Medicine (nekken) Nagasaki University

• Uyen Dinh

  Department Of Applied Biology Kyoto Institute Of Technology

• Huy Nguyen

  Department Of Applied Biology Kyoto Institute Of Technology:department Of Immunogenetics Institute O

• Hirayama Kenji

  Department Of Clinical Immunology Medical Institute Of Bioregulation Kyushu University

• Kamei K

  Kyoto Inst. Technol. Kyoto Jpn

• Oida Tatsuo

  Department Of Materials And Science Kyoto Institute Of Technology

• Nguyen Thanh

  Department Of Environmental Information Studies And Analysis Institute Of Geography Ncst Of Vietnam

• KAMEI Kaeko

  Department of Chemistry and Materials Technology, Faculty of Engineering and Design, Kyoto Institute

• HARADA Shigeharu

  Department of Applied Biology, Kyoto Institute of Technology

• Nhien Nguyen

  Department Of Applied Biology Kyoto Institute Of Technology

• TRANG Dai

  Department of Applied Biology, Kyoto Institute of Technology

• Trang Dai

  Department Of Applied Biology Kyoto Institute Of Technology

• Kudo Ken-ichi

  Sanwa Cornstarch Co. Ltd

• Harada Shigeharu

  Department Of Applied Biology Kyoto Institute Of Technology

• Kamei Kaeko

  Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology

• Oida Tatsuo

  Department Of Chemistry And Materials Technology Kyoto Institute Of Technology

• Hirayama Kenji

  Department Of Immunogenetics Institute Of Tropical Medicine Nagasaki University

• Nguyen Thanh

  Department of Electrical and Electronic Engineering, National Defense Academy, Yokosuka, Kanagawa 239-8686, Japan

• Kamei Kaeko

  Department fo Chemistry and Materials Technology, Faculty of Engineering and Design, Kyoto Institute of Technology

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