The Association of Cytokines with Severe Dengue in Children
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概要
- 論文の詳細を見る
Background: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. Methods & Findings: In a hospital based case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex Immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, the multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. Conclusion: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to further investigate the function of these cytokines in severe dengue.
- 日本熱帯医学会の論文
著者
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Huy Nguyen
Department Of Applied Biology Kyoto Institute Of Technology:department Of Immunogenetics Institute O
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Hirayama Kenji
Department Of Clinical Immunology Medical Institute Of Bioregulation Kyushu University
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LAN Nguyen
Department of Microbiology - Infectious Diseases - Pathology, Faculty of Veterinary Medicine, Hanoi University of Agriculture, Trau Quy, Gia Lam, Ha Noi, Vietnam
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Ha Tran
Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City
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Nga Cao
Center for Preventive Medicine
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Tuong Vo
Center for Preventive Medicine
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Bao Lam
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
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Huong Vu
Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City
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Thuy Tran
Children's Hospital No.2
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Mangione Julia
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
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Mbanefo Evaristus
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
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Dat Tran
Center for Preventive Medicine
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Tuan Ha
Children's Hospital No.2
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Tuan Ha
Children's Hospital No.2
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Lan Nguyen
Department of Immunology & Microbiology, Pasteur Institute in Ho Chi Minh City
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