Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
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概要
- 論文の詳細を見る
Bletilla striata, a traditional Chinese medicine, has been used for the treatment of alimentary canal mucosal damage, ulcers, bleeding, bruises and burns. B. striata polysaccharide (BSP) isolated from B. striata was found to enhance vascular endothelial cell(EC) proliferation and vascular endothelial growth factor(VEGF) expression. However, the wound healing mechanism of BSP is not well understood. In this study, the results show that treatment with BSP induces coordinate changes in inducible nitric oxide synthase(iNOS), tumor necrosis factor alpha(TNF-α) and interleukin 1 beta (IL-1β) mRNA levels and enhances the expression of these cytokines, but has no effect on interferon gamma (IFN-γ) level. In this study, we partially elucidate the wound healing mechanism of BSP.
- 社団法人日本生物工学会の論文
- 2008-02-25
著者
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Chen Xi
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Dong Lei
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Luo Yi
State Key Laboratory On Integrated Optoelectronics Tsinghua National Laboratory For Information Scie
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LI Xin
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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Diao Huajia
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Chen Jiangning
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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Wang Chunming
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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Zhang Chenyu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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Zhang Junfeng
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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Luo Yi
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Luo Yi
State Key Lab On Integrated Optoelectronics Department Of Electronic Engineering Tsinghua University
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Zhang Chenyu
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University:jian
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Zhang Junfeng
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University:jian
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Wang Chunming
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Chen Jiangning
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University:jian
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Li Xin
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Li Xin
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Luo Yi
State Key Lab of Integrated Optoelectronics, Department of Electronic Engineering, Tsinghua University, Beijing 100084, P. R. China
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Dong Lei
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Chen Xi
State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China
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Luo Yi
State Key Lab of Integrated Optoelectronics, Department of Electronic Engineering, Tsinghua University
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