Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1
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概要
- 論文の詳細を見る
Two novel splice variants of CDK5RAP1, named CDK5RAP1_v3 and CDK5RAP1_v4, were isolated through the large-scale sequencing analysis of a human fetal brain cDNA library. The CDK5RAP1_v3 and CDK5RAP1_v4 cDNAs are 1923bp and 1792bp in length, respectively. Sequence analysis revealed that CDK5RAP1_v4 lacked 1 exon, which was present in CDK5RAP1_v3, with the result that these cDNAs encoded different putative proteins. The deduced proteins were 574 amino acids (designated as CDK5RAP1_v3) and 426 amino acids (CDK5RAP1_v4) in length, and shared the 420 N-terminal amino acids. RT-PCR analysis showed that human CDK5RAP1_v3 was widely expressed in human tissues. The expression level of CDK5RAP1_v3 was relatively high in placenta and lung, whereas low levels of expression were detected in heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, small intestine and peripheral blood leukocytes. In contrast, human CDK5RAP1_v4 was mainly expressed in brain, placenta and testis.
- 日本遺伝学会の論文
- 2004-06-25
著者
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Xie Y
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Science Fudan Unive
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Xie Yi
中華人民共和国
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Ye X
Fudan Univ. Shanghai Chn
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Xie Yi
Structure Research Laboratory Laboratory Of Nanochemistry And Nanomaterials University Of Science An
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Xie Y
Univ. Sci. Technol. China Anhui Chn
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Xie Yi
State Key Lab. Of Genetic Engineering Inst. Of Genetics School Of Life Sciences Fudan Univ.
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Xu J
Univ. California Ca Usa
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Fan Jingping
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Mao Yumin
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Science Fudan Unive
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JI Chaoneng
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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GU Shaohua
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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ZOU Xianqiong
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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JIN Feng
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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LIU Jianping
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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WU Maoqing
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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ZHENG Huarui
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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WANG Yu
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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LI Xin
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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XU Jian
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan U
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Gu Shaohua
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Science Fudan Unive
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Xu Jian
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Ji Chaoneng
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Ma Yushu
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Xiong Y
Structure Research Laboratory And Department Of Materials Science And Engineering University Of Scie
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Wu Maoqing
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Zheng Huarui
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Liu Jianping
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Zou Xianqiong
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Li Xin
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Wang Yu
State Key Laboratory Of Genetic Engineering Institute Of Genetics School Of Life Sciences Fudan Univ
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Wang Yu
State Key Laboratory Of C1 Chemical Technology And Tianjin University-abb Plasma Greenhouse Gas Chem
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