Zinc Bioavailability Is Improved by the Micronised Dispersion of Zinc Oxide with the Addition of L-Histidine in Zinc-Deficient Rats

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概要

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• Zinc fortification of milk or soft drinks is usually used to combat zinc deficiencies in developing countries. Water-soluble zinc compounds, such as zinc sulfate or zinc citrate, are better absorbed but have an unacceptable taste. A micronised, dispersible zinc oxide (MDZnO), which does not have such a problem concerning taste, had higher solubility compared to ZnO (zinc oxide) in an artificial gastric solution. MDZnO was tested for its bioavail-ability using zinc-deficient Wistar rats. Prior to the experiment, rats were fed zinc-deficient diet for 3 wk and were orally administered control (distilled water) or zinc solutions (ZnO, ZnO+L-histidine (His), MDZnO, MDZnO+His, 1 mg zinc/kg or 3.2 mg His/kg body weight). Compared to ZnO, MDZnO showed a lag in peak time and a lengthy period of continued high plasma zinc concentration after the single oral administration of zinc compounds. Addition of His to MDZnO elevated serum zinc concentration. Serum zinc concentration (area under the curve) in rats administered MDZnO with His was significantly higher than in rats administered distilled water (p<0.05). Liver zinc level was significantly higher in rats administered MDZnO with His compared with control rats (p<0.05), although the level was not affected by the administration with ZnO alone, ZnO+His, or MDZnO alone. In conclusion, the solubility of ZnO was elevated by the micronised dispersion tecnique and an in vivo study using zinc-deficient rats confirmed that its bioavailability was significantly improved compared to ZnO and the coadministration of His additively enhanced the bioavailability of MDZnO.

• 日本ビタミン学会の論文

著者

• MITA Yukiko

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• ISHIHARA Kengo

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• YASUMOTO Kyoden

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• Oka Tatsuo

  Nano Function Divisions Taiyo Kagaku Co. Ltd.

• Mita Yukiko

  Department Of Food And Nutrition School Of Life Studies Sugiyama Jogakuen University

• Takeda Masako

  Department Of Human Nutrition School Of Life Studies Sugiyama Jogakuen University

• Ishihara K

  Department Of Food And Nutrition School Of Life Studies Sugiyama Jogakuen University

• Ishihara Kengo

  Department Of Food And Nutrition Sugiyama Jogakuen University

• Yasumoto K

  Department Of Food And Nutrition School Of Life Studies Sugiyama Jogakuen University

• Yasumoto Kyoden

  Department Of Food And Nutrition School Of Life Studies Sugiyama Jogakuen University

• YAMANAMI Kaori

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• TAKANO Mami

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• SUZUMURA Aya

  Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University

• JUNEJA Lekh

  Nano Function Divisions, Taiyo Kagaku Co. LTd.

• Suzumura Aya

  Department Of Human Nutrition School Of Life Studies Sugiyama Jogakuen University

• Yamanami Kaori

  Department Of Human Nutrition School Of Life Studies Sugiyama Jogakuen University

• Juneja Lekh

  Nano Function Divisions Taiyo Kagaku Co. Ltd.

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