Effect of Dietary Mannooligosaccharides on the Immune System of Ovalbumin-Sensitized Mice

概要

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The effects of the dietary mannooligosaccharides (MOS) from coffee mannan on the anti-allergic functions were examined using C3H/HeN mice. The mice were given water and a dietary treatment containing 2.5% MOS ad libitum. The mice were sensitized subcutaneously with ovalbumin on the 7th, 21st, and 35th days and then sensitized intraperitoneally on the 49th day of the study. Serum samples, Peyer's patches and peritoneal exudate fluids were collected on the 50th day. In the non-ovalbumin sensitized groups, phosphate-buffered saline (PBS) was injected instead of ovalbumin. The number of peritoneal acidophils in the MOS diet-fed mice, was significantly lower than that in the control diet-fed ones. MOS treatment significantly reduced interleukin-10 production and tended to suppress ovalbumin-specific IgE in serum. However, it did not change interleukin-2 and interferon-γ production. These results suggest that dietary MOS may have an anti-allergic effect, caused by activation of cellular immunity.
公益社団法人日本薬学会の論文
2007-12-01